ID   CP2AX_BOVIN             Reviewed;          18 AA.
AC   P22779;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   12-AUG-2020, entry version 84.
DE   RecName: Full=Cytochrome P450 2A;
DE            EC=1.14.14.1;
DE   AltName: Full=Cytochrome OLF2;
DE   AltName: Full=Olfactive cytochrome P450;
DE   AltName: Full=P52;
DE   Flags: Fragment;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   PROTEIN SEQUENCE.
RX   PubMed=2121272; DOI=10.1021/bi00484a012;
RA   Lazard D., Tal N., Rubinstein M., Khen M., Lancet D., Zupko K.;
RT   "Identification and biochemical analysis of novel olfactory-specific
RT   cytochrome P-450IIA and UDP-glucuronosyl transferase.";
RL   Biochemistry 29:7433-7440(1990).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       In liver microsomes, this enzyme is involved in an NADPH-dependent
CC       electron transport pathway. It oxidizes a variety of structurally
CC       unrelated compounds, including steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   PIR; A35704; A35704.
DR   STRING; 9913.ENSBTAP00000054604; -.
DR   PRIDE; P22779; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Endoplasmic reticulum; Heme; Iron; Membrane;
KW   Metal-binding; Microsome; Monooxygenase; Olfaction; Oxidoreductase;
KW   Reference proteome; Sensory transduction.
FT   CHAIN           <1..>18
FT                   /note="Cytochrome P450 2A"
FT                   /id="PRO_0000051677"
FT   VARIANT         6
FT                   /note="G -> D"
FT   VARIANT         11
FT                   /note="A -> E"
FT   NON_TER         1
FT   NON_TER         18
SQ   SEQUENCE   18 AA;  2060 MW;  F80746F76CCD77FF CRC64;
     MXYLPGPQQQ AFKELQGL