CP2B_DROPS
ID CP2B_DROPS Reviewed; 155 AA.
AC Q29CA0;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Cardio acceleratory peptide 2b;
DE AltName: Full=Capability protein;
DE AltName: Full=Myotropin-CAP2b-like protein;
DE Contains:
DE RecName: Full=CAP-1;
DE Contains:
DE RecName: Full=CAP-2;
DE Contains:
DE RecName: Full=CAP-3;
DE AltName: Full=Pyrokinin-1;
DE Flags: Precursor;
GN Name=capa {ECO:0000250|UniProtKB:Q9NIP6}; ORFNames=GA13779;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa
CC receptor. CAP-1 and CAP-2 are probably components of the signal
CC transduction pathway that leads to Malpighian tubule fluid secretion
CC via the second messenger nitric oxide (By similarity).
CC {ECO:0000250|UniProtKB:Q9NIP6}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9NIP6}.
CC -!- SIMILARITY: Belongs to the pyrokinin family. {ECO:0000255}.
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DR EMBL; CM000070; EAL26746.2; -; Genomic_DNA.
DR RefSeq; XP_001357612.2; XM_001357575.3.
DR AlphaFoldDB; Q29CA0; -.
DR STRING; 7237.FBpp0282948; -.
DR EnsemblMetazoa; FBtr0284510; FBpp0282948; FBgn0073815.
DR GeneID; 4800261; -.
DR KEGG; dpo:Dpse_GA13779; -.
DR eggNOG; ENOG502TAG0; Eukaryota.
DR HOGENOM; CLU_1697372_0_0_1; -.
DR InParanoid; Q29CA0; -.
DR OMA; SMLVHIV; -.
DR Proteomes; UP000001819; Chromosome 2.
DR Bgee; FBgn0073815; Expressed in insect adult head.
DR GO; GO:0005576; C:extracellular region; ISS:UniProtKB.
DR GO; GO:0016084; F:myostimulatory hormone activity; ISS:UniProtKB.
DR GO; GO:0005184; F:neuropeptide hormone activity; ISS:UniProtKB.
DR GO; GO:0007218; P:neuropeptide signaling pathway; ISS:UniProtKB.
DR InterPro; IPR013231; Periviscerokinin.
DR Pfam; PF08259; Periviscerokin; 1.
DR PROSITE; PS00539; PYROKININ; 1.
PE 3: Inferred from homology;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT PROPEP 27..33
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT /id="PRO_0000339244"
FT PEPTIDE 36..47
FT /note="CAP-1"
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT /id="PRO_0000339245"
FT PROPEP 50..85
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT /id="PRO_0000339246"
FT PEPTIDE 88..96
FT /note="CAP-2"
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT /id="PRO_0000339247"
FT PROPEP 99..117
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT /id="PRO_0000339248"
FT PEPTIDE 120..134
FT /note="CAP-3"
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT /id="PRO_0000339249"
FT PROPEP 138..155
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT /id="PRO_0000339250"
FT MOD_RES 47
FT /note="Valine amide"
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT MOD_RES 96
FT /note="Valine amide"
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
FT MOD_RES 134
FT /note="Leucine amide"
FT /evidence="ECO:0000250|UniProtKB:Q9NIP6"
SQ SEQUENCE 155 AA; 16958 MW; 4572C392A8F91481 CRC64;
MKAIFSLYNI VSAILLLVLL AEFSTAELNH DKNRRGANMG LYAFPRVGRS DPSLANSLRD
ASDAAVFDGL YGDASQEDYN EADYQKRAGL VAFPRVGRSD AELRKFAHLL ALQQVLDKRT
GPSASSGLWF GPRLGKRSVD AKAFSDASKG QQEFN
