ID   CP2CU_RABIT             Reviewed;         489 AA.
AC   Q29510;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Cytochrome P450 2C30;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIIC30;
GN   Name=CYP2C30;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=New Zealand white; TISSUE=Liver;
RA   Noshiro M., Ishida H., Okuda K.;
RT   "A member of cytochrome P450 2C family.";
RL   Submitted (JAN-1994) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       In liver microsomes, this enzyme is involved in an NADPH-dependent
CC       electron transport pathway. It oxidizes a variety of structurally
CC       unrelated compounds, including steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- INDUCTION: P450 can be induced to high levels in liver and other
CC       tissues by various foreign compounds, including drugs, pesticides, and
CC       carcinogens.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; D26153; BAA05140.1; -; mRNA.
DR   RefSeq; NP_001164737.1; NM_001171266.1.
DR   AlphaFoldDB; Q29510; -.
DR   SMR; Q29510; -.
DR   STRING; 9986.ENSOCUP00000027204; -.
DR   GeneID; 100328935; -.
DR   KEGG; ocu:100328935; -.
DR   CTD; 100328935; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   InParanoid; Q29510; -.
DR   OrthoDB; 702827at2759; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008067; Cyt_P450_E_grp-I_CYP2A-like.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01684; EP450ICYP2A.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..489
FT                   /note="Cytochrome P450 2C30"
FT                   /id="PRO_0000051718"
FT   BINDING         434
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   489 AA;  55915 MW;  F2459438D858FB69 CRC64;
     MDLFIVLVIC LSCLLLVSLL KQSYARRKLP PGPTAFPLVG NVLQLDRKNI SKSISMLAKE
     YGPVFTVYFG TKPSVVLHGY EAVKEALVDH GEEFSGRVTV PVFDRYAQGA GLFASQGELW
     KETRRFTLTV LRNMGMGKKT IEDRIQEEAS CLVKALKETN ASPCDPSSLL FCVPCNVICS
     IIFQNRFEYN DQTFQTLVKH FLDSIRLFNT PWMQLYNTFP ILHYLPGSHH ELFKVFNDQM
     KFFSEKIREH QESLDHNNPR DFIDYLLIKM EKEKHNKQSQ FTMHHLLVTI WDVFDAGSQT
     TSSTMQFGLL LLMKHPEIAA KVQEEIERVI GRDRSPCMQD RSCMPYTDAV IHEIQRYIDM
     VPNNVPHAVT QDIQFRGYLI PKGTHILPSL TSVLYDEKEF PNPEKFDPGH FLDASGNFKK
     SDYFLPFSIG KRACAGEGLA RMELFLVLTT ILQHFTLKPL VDPKDIDPTP VDNGFLSVPP
     SYELCFVPV