ID   CP2DK_MESAU             Reviewed;         500 AA.
AC   Q9QYG5;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Cytochrome P450 2D20;
DE            EC=1.14.14.-;
DE   AltName: Full=CYPIID20;
GN   Name=CYP2D20;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=11083025; DOI=10.1016/s0742-8413(00)00142-0;
RA   Oka T., Fukuhara M., Ushio F., Kurose K.;
RT   "Molecular cloning and characterization of three novel cytochrome P450 2D
RT   isoforms, CYP2D20, CYP2D27, and CYP2D28 in the Syrian hamster (Mesocricetus
RT   auratus).";
RL   Comp. Biochem. Physiol. 127C:143-152(2000).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Microsome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AB031864; BAA89313.1; -; mRNA.
DR   AlphaFoldDB; Q9QYG5; -.
DR   SMR; Q9QYG5; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01686; EP450ICYP2D.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..500
FT                   /note="Cytochrome P450 2D20"
FT                   /id="PRO_0000051744"
FT   BINDING         446
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   500 AA;  56503 MW;  9948102706C50144 CRC64;
     MVLLIGDGLW SGVIFTALFL LLVDLMHRRK FWRARYPPGP MPLPGLGNLL QVDFENMPYS
     LYKFQQRYGD VFSLQMAWKP VVVINGLKAV REVLVNCGED TADRPPVPIF NHLGYRPKSQ
     GVVFARYGPQ WREQRRFSVS TMRDFGVGKK SLEQWVTEEA GHLCDAFTQE AGHPFNPITL
     LNKSVCNVIS SLIYAHRFDY EDPFFNKLLK TLQESFGEDS GFIAEVLNAV PVLLRIPGLP
     GKAFPKLTAF MDSLYKMLIE HKTTWDPAQP PRGLTDAFLA EVEKAKGRPE SSFNDENLHV
     VVADLFIAGM VTTSTTLSWA LLLMILHPDV QSRVQQEIDD VIGQVRRPEM ADQARMPYTN
     AVIHEVQRFG DIAPVNVPHM TSRDVEVQGF LIPKGTTLIP NLSSVLKDET VWEKPLHFHP
     EHFLDAQGRF VKQEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VPAGQPRPSD
     QGVFALPVTP TPYELCAVVR