ID   CP2DS_MESAU             Reviewed;         500 AA.
AC   Q9QUJ1;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 98.
DE   RecName: Full=Cytochrome P450 2D28;
DE            EC=1.14.14.-;
DE   AltName: Full=CYPIID28;
GN   Name=CYP2D28A;
GN   and
GN   Name=CYP2D28B;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=11083025; DOI=10.1016/s0742-8413(00)00142-0;
RA   Oka T., Fukuhara M., Ushio F., Kurose K.;
RT   "Molecular cloning and characterization of three novel cytochrome P450 2D
RT   isoforms, CYP2D20, CYP2D27, and CYP2D28 in the Syrian hamster (Mesocricetus
RT   auratus).";
RL   Comp. Biochem. Physiol. 127C:143-152(2000).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Peripheral membrane protein {ECO:0000250}. Microsome membrane
CC       {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AB031865; BAA89314.1; -; mRNA.
DR   EMBL; AB031866; BAA89315.1; -; mRNA.
DR   RefSeq; NP_001297489.1; NM_001310560.1.
DR   AlphaFoldDB; Q9QUJ1; -.
DR   SMR; Q9QUJ1; -.
DR   STRING; 10036.XP_005066924.1; -.
DR   GeneID; 101840984; -.
DR   eggNOG; KOG0156; Eukaryota.
DR   OrthoDB; 702827at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0016712; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR008069; Cyt_P450_E_grp-I_CYP2D-like.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR01686; EP450ICYP2D.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..500
FT                   /note="Cytochrome P450 2D28"
FT                   /id="PRO_0000051749"
FT   BINDING         446
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   500 AA;  56571 MW;  B34D8006D0D73203 CRC64;
     MELLTGHGLW PVAMFTVILI LLVDLLHRRQ RWASRYPPGP VPLPLLGNLL QVDLKNMQYS
     VHKLQQHYGD VFSLQMAWKH MVMINGLKAV REVLVNYGEY TADRPKIPIY EHGSLGPKAR
     GVILAPYGPE WREQRRFSVS TLRNLGLGKK SLEQWVTDEA GHLCDAFKDQ AGRPFNPSTL
     LNKAVCNVIT SLIFARRFEY EDANLIRMLR LLEEALTNIS GFIPEILNTF PVLLHIPGLF
     DKVFSGQKTF AAIVDNLLTE NRRTWDPEQP PRGLTDAFLA EMEKAKGNPE SSFNDQNLRM
     VVNDLFIAGT VSTSTTLSWA LLFMIQYPDV QRRVQQEIDD ILGPGRSPEM ADQARMPYTN
     AVIHEVQRFA DIAPLNLPCI TSRDIEVQGF LIPKGTTLIT NLSSVLKDET VWEKPLHFHP
     EHFLDAQGCF VKQEAFMPFS AGRRACLGEP LARMELFLFF TCLLQRFSFS VPAGQPRPSD
     HVVLGVLKSP APYQLCAVPR