CP2_APLCA
ID CP2_APLCA Reviewed; 141 AA.
AC Q8T0Y7;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 44.
DE RecName: Full=Neuropeptides CP2;
DE Contains:
DE RecName: Full=CP2-derived peptide 1;
DE Contains:
DE RecName: Full=CP2-derived peptide 2;
DE Contains:
DE RecName: Full=CP2-derived peptide 3;
DE Contains:
DE RecName: Full=CP2-derived peptide 4;
DE Contains:
DE RecName: Full=CP2-derived peptide 5;
DE Contains:
DE RecName: Full=CP2-derived peptide 6;
DE Contains:
DE RecName: Full=CP2-derived peptide 7;
DE Contains:
DE RecName: Full=CP2-derived peptide 8;
DE Contains:
DE RecName: Full=CP2-derived peptide 9;
DE Contains:
DE RecName: Full=CP2-derived peptide 10;
DE Contains:
DE RecName: Full=Neuropeptide CP2;
DE AltName: Full=Neuropeptide cerebral peptide 2;
DE Flags: Precursor;
GN Name=CP2PP;
OS Aplysia californica (California sea hare).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC Aplysiidae; Aplysia.
OX NCBI_TaxID=6500;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 27-68; 27-31; 34-68; 69-97;
RP 69-87; 69-86; 69-83; 69-74; 89-97 AND 89-95, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, AMIDATION AT HIS-140, AND MASS SPECTROMETRY.
RC TISSUE=CNS;
RX PubMed=11786187; DOI=10.1016/s0196-9781(01)00561-7;
RA Vilim F.S., Alexeeva V., Moroz L.L., Li L., Moroz T.P., Sweedler J.V.,
RA Weiss K.R.;
RT "Cloning, expression and processing of the CP2 neuropeptide precursor of
RT Aplysia.";
RL Peptides 22:2027-2038(2001).
RN [2]
RP FUNCTION.
RX PubMed=10979994; DOI=10.1152/jn.2000.84.3.1186;
RA Morgan P.T., Perrins R., Lloyd P.E., Weiss K.R.;
RT "Intrinsic and extrinsic modulation of a single central pattern generating
RT circuit.";
RL J. Neurophysiol. 84:1186-1193(2000).
CC -!- FUNCTION: Mediates intrinsic neuromodulation.
CC {ECO:0000269|PubMed:10979994}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11786187}.
CC -!- TISSUE SPECIFICITY: Neurons. {ECO:0000269|PubMed:11786187}.
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 2]: Mass=622.30; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 8]: Mass=636.36; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 10]: Mass=832.34; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 9]: Mass=1047.43; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 7]: Mass=1701.85; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 6]: Mass=2045.81; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 5]: Mass=2133.12; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 4]: Mass=3319.30; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 3]: Mass=3779.20; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [Neuropeptide CP2]: Mass=4592; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
CC -!- MASS SPECTROMETRY: [CP2-derived peptide 1]: Mass=4695.38; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:11786187};
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DR EMBL; AY033828; AAK56550.1; -; mRNA.
DR PIR; A57272; A57272.
DR RefSeq; NP_001191491.1; NM_001204562.1.
DR AlphaFoldDB; Q8T0Y7; -.
DR GeneID; 100533251; -.
DR CTD; 100533251; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Secreted; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000269|PubMed:11786187"
FT PEPTIDE 27..68
FT /note="CP2-derived peptide 1"
FT /evidence="ECO:0000269|PubMed:11786187"
FT /id="PRO_0000265124"
FT PEPTIDE 27..31
FT /note="CP2-derived peptide 2"
FT /id="PRO_0000265125"
FT PEPTIDE 34..68
FT /note="CP2-derived peptide 3"
FT /evidence="ECO:0000269|PubMed:11786187"
FT /id="PRO_0000265126"
FT PEPTIDE 69..97
FT /note="CP2-derived peptide 4"
FT /id="PRO_0000265127"
FT PEPTIDE 69..87
FT /note="CP2-derived peptide 5"
FT /id="PRO_0000265128"
FT PEPTIDE 69..86
FT /note="CP2-derived peptide 6"
FT /id="PRO_0000265129"
FT PEPTIDE 69..83
FT /note="CP2-derived peptide 7"
FT /id="PRO_0000265130"
FT PEPTIDE 69..74
FT /note="CP2-derived peptide 8"
FT /id="PRO_0000265131"
FT PEPTIDE 89..97
FT /note="CP2-derived peptide 9"
FT /id="PRO_0000265132"
FT PEPTIDE 89..95
FT /note="CP2-derived peptide 10"
FT /id="PRO_0000265133"
FT PEPTIDE 100..140
FT /note="Neuropeptide CP2"
FT /id="PRO_0000265134"
FT REGION 75..94
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 140
FT /note="Histidine amide"
FT /evidence="ECO:0000269|PubMed:11786187"
SQ SEQUENCE 141 AA; 15654 MW; B32BDC841E272BFB CRC64;
MDSRICTSFA RLMASALCVS TLLVTAMPFD LRRGSSDTDL DLQGHVDLGL DDLDKLRLIF
PPGLIEEAFS QAQGKVDMPL PRQRTSSRSS ERWAPKSKRF DFGFAGLDTY DAIHRALEQP
ARGTSNSGSG YNMLMKMQRH G
