位置:首页 > 蛋白库 > CP3A9_RAT
CP3A9_RAT
ID   CP3A9_RAT               Reviewed;         503 AA.
AC   P51538; Q64557; Q64631;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 136.
DE   RecName: Full=Cytochrome P450 3A9;
DE            EC=1.14.14.1;
DE   AltName: Full=3AH15;
DE   AltName: Full=CYPIIIA9;
DE   AltName: Full=Cytochrome P450 olfactive 3;
DE   AltName: Full=Cytochrome P450-OLF3;
GN   Name=Cyp3a9; Synonyms=Cyp3a13;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   PubMed=8990268; DOI=10.1006/abbi.1996.9752;
RA   Mahnke A., Strotkamp D., Roos P.H., Hanstein W.G., Chabot G.G., Nef P.;
RT   "Expression and inducibility of cytochrome P450 3A9 (CYP3A9) and other
RT   members of the CYP3A subfamily in rat liver.";
RL   Arch. Biochem. Biophys. 337:62-68(1997).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=8660328; DOI=10.1006/bbrc.1996.0562;
RA   Wang H., Kawashima H., Strobel H.W.;
RT   "cDNA cloning of a novel CYP3A from rat brain.";
RL   Biochem. Biophys. Res. Commun. 221:157-162(1996).
CC   -!- FUNCTION: This isozyme seems to be implicated in olfaction. Active in
CC       the demethylation of erythromycin as well as benzphetamine.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in olfactory epithelium.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; U60085; AAB03662.1; -; mRNA.
DR   EMBL; U46118; AAC52582.1; -; mRNA.
DR   PIR; JC4702; JC4702.
DR   AlphaFoldDB; P51538; -.
DR   SMR; P51538; -.
DR   STRING; 10116.ENSRNOP00000067681; -.
DR   ChEMBL; CHEMBL3430866; -.
DR   UCSC; RGD:708392; rat.
DR   RGD; 708392; Cyp3a9.
DR   InParanoid; P51538; -.
DR   PhylomeDB; P51538; -.
DR   Reactome; R-RNO-211958; Miscellaneous substrates.
DR   Reactome; R-RNO-211981; Xenobiotics.
DR   PRO; PR:P51538; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0101020; F:estrogen 16-alpha-hydroxylase activity; ISO:RGD.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; ISS:UniProtKB.
DR   GO; GO:0016491; F:oxidoreductase activity; ISO:RGD.
DR   GO; GO:0008401; F:retinoic acid 4-hydroxylase activity; ISO:RGD.
DR   GO; GO:0008395; F:steroid hydroxylase activity; TAS:RGD.
DR   GO; GO:0009822; P:alkaloid catabolic process; ISO:RGD.
DR   GO; GO:0008210; P:estrogen metabolic process; ISO:RGD.
DR   GO; GO:0007565; P:female pregnancy; IEP:RGD.
DR   GO; GO:0002933; P:lipid hydroxylation; ISO:RGD.
DR   GO; GO:0070989; P:oxidative demethylation; ISO:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; ISO:RGD.
DR   GO; GO:0071548; P:response to dexamethasone; IEP:RGD.
DR   GO; GO:0032355; P:response to estradiol; IEP:RGD.
DR   GO; GO:0043627; P:response to estrogen; IEP:RGD.
DR   GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR   GO; GO:0010043; P:response to zinc ion; IEP:RGD.
DR   GO; GO:0042573; P:retinoic acid metabolic process; ISO:RGD.
DR   GO; GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
DR   GO; GO:0008202; P:steroid metabolic process; ISO:RGD.
DR   GO; GO:0042178; P:xenobiotic catabolic process; ISO:RGD.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR008072; Cyt_P450_E_CYP3A.
DR   InterPro; IPR002402; Cyt_P450_E_grp-II.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00464; EP450II.
DR   PRINTS; PR01689; EP450IICYP3A.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Olfaction; Oxidoreductase; Reference proteome;
KW   Sensory transduction.
FT   CHAIN           1..503
FT                   /note="Cytochrome P450 3A9"
FT                   /id="PRO_0000051792"
FT   BINDING         442
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        457
FT                   /note="F -> V (in Ref. 2; AAC52582)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   503 AA;  57812 MW;  9BBB13E690675EB4 CRC64;
     MDLIPNFSME TWLLLVISLV LLYLYGTHSH GIFKKLGIPG PKPLPFLGTI LAYRKGFWEF
     DKYCHKKYGK LWGLYDGRQP VLAITDPDII KTVLVKECYS TFTNRRNFGP VGILKKAISI
     SEDEEWKRIR ALLSPTFTSG KLKEMFPIIN QYTDMLVRNM RQGSEEGKPT SMKDIFGAYS
     MDVITATSFG VNVDSLNNPQ DPFVEKVKKL LKFDIFDPLF LSVTLFPFLT PLFEALNVSM
     FPRDVIDFFK TSVERMKENR MKEKEKQRMD FLQLMINSQN SKVKDSHKAL SDVEIVAQSV
     IFIFAGYETT SSALSFVLYL LAIHPDIQKK LQDEIDAALP NKAHATYDTL LQMEYLDMVV
     NETLRLYPIA GRLERVCKTD VEINGVFIPK GTVVMIPTFA LHKDPHYWPE PEEFRPERFS
     KKNQDNINPY MYLPFGNGPR NCIGMRFALM NMKVALFRVL QNFSFQPCKE TQIPLKLSKQ
     GLLQPEKPLL LKVVSRDETV NGA
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024