ID   CP3AV_MESAU             Reviewed;         501 AA.
AC   O70537;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Cytochrome P450 3A31;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIIIA31;
DE   AltName: Full=Cytochrome P450 SH3A-1;
GN   Name=CYP3A31;
OS   Mesocricetus auratus (Golden hamster).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Cricetinae; Mesocricetus.
OX   NCBI_TaxID=10036;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Liver;
RX   PubMed=9545515; DOI=10.1016/s0167-4781(97)00220-0;
RA   Alabouch S., Kurose K., Tohkin M., Bani M.-H., Fukuhara M., Nagata K.,
RA   Yamazoe Y.;
RT   "cDNA cloning and expression of a novel CYP3A from the Syrian hamster,
RT   CYP3A31.";
RL   Biochim. Biophys. Acta 1397:9-13(1998).
CC   -!- FUNCTION: Cytochromes P450 are a group of heme-thiolate monooxygenases.
CC       In liver microsomes, this enzyme is involved in an NADPH-dependent
CC       electron transport pathway. It oxidizes a variety of structurally
CC       unrelated compounds, including steroids, fatty acids, and xenobiotics.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed constitutively in liver.
CC   -!- INDUCTION: Induced by phenobarbital and repressed by 3-
CC       methylcholanthrene or dexamethasone.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; D86951; BAA25811.1; -; mRNA.
DR   RefSeq; NP_001268529.1; NM_001281600.1.
DR   AlphaFoldDB; O70537; -.
DR   SMR; O70537; -.
DR   STRING; 10036.XP_005080074.1; -.
DR   GeneID; 101836914; -.
DR   eggNOG; KOG0158; Eukaryota.
DR   OrthoDB; 467733at2759; -.
DR   Proteomes; UP000189706; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR008072; Cyt_P450_E_CYP3A.
DR   InterPro; IPR002402; Cyt_P450_E_grp-II.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00464; EP450II.
DR   PRINTS; PR01689; EP450IICYP3A.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..501
FT                   /note="Cytochrome P450 3A31"
FT                   /id="PRO_0000051811"
FT   BINDING         440
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   501 AA;  57772 MW;  D6C32CEEAB056589 CRC64;
     MDLTSVLSLE TWVLLAISLV LLYRLGTHKY DIFKKQGIPG PKPLPFLGNV LNYYKGIWTF
     DIECHKKYGK IWGLFEGQRP LFTVTDTEMI KNVLVKECYS IFTNRRDFGP VGIMSKAVSI
     SKDEEWKRIR ALLSPTFTSG KLKEMFPIIE QYGDILVKFL RREAEKGNPV TTKEVFGAYS
     MDVITSTAFG VSVDSLNNPK DLLWKGRKLL RFDFFDPLFL SVVLFPFLIP IYEKLNVSMF
     PKDSISFFRK FVDKTKENRL DYNQKHRVDF LQLMMNSHDN SKDSHKALSD MEIIAQSIIF
     IFAGYDTTSS TLSFALYLLA THPDVQKKLQ EEIDIALPNK ARPSYDKVME MEYLDMVLNE
     TLRLYPIGSR LERVCKQDVE MDGVFVPKGS IVMVPVFALH YDPQYWPEPE KFRPERFSKE
     NKGSIDPYIF LPFGNGPRNC IGMRFALMNM KLALTKVLQN FSLQPCKETQ IPMKLSRKAM
     LQPEKPIILK VVPRDAIITG A