ID   CP4F6_RAT               Reviewed;         537 AA.
AC   P51871;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 149.
DE   RecName: Full=Cytochrome P450 4F6;
DE            EC=1.14.14.1;
DE   AltName: Full=CYPIVF6;
GN   Name=Cyp4f6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Brain;
RX   PubMed=8554568; DOI=10.1006/bbrc.1995.2887;
RA   Kawashima H., Strobel H.W.;
RT   "cDNA cloning of three new forms of rat brain cytochrome P450 belonging to
RT   the CYP4F subfamily.";
RL   Biochem. Biophys. Res. Commun. 217:1137-1144(1995).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=an organic molecule + O2 + reduced [NADPH--hemoprotein
CC         reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein
CC         reductase]; Xref=Rhea:RHEA:17149, Rhea:RHEA-COMP:11964, Rhea:RHEA-
CC         COMP:11965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:30879, ChEBI:CHEBI:57618, ChEBI:CHEBI:58210,
CC         ChEBI:CHEBI:142491; EC=1.14.14.1;
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000250|UniProtKB:P51869};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral
CC       membrane protein. Microsome membrane; Peripheral membrane protein.
CC   -!- TISSUE SPECIFICITY: High expression in liver and kidney. Lower
CC       expression in brain.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; U39208; AAC52360.1; -; mRNA.
DR   PIR; JC4534; JC4534.
DR   RefSeq; NP_695230.1; NM_153318.1.
DR   AlphaFoldDB; P51871; -.
DR   SMR; P51871; -.
DR   STRING; 10116.ENSRNOP00000059924; -.
DR   ChEMBL; CHEMBL3509599; -.
DR   PhosphoSitePlus; P51871; -.
DR   PaxDb; P51871; -.
DR   GeneID; 266689; -.
DR   KEGG; rno:266689; -.
DR   UCSC; RGD:708365; rat.
DR   CTD; 266689; -.
DR   RGD; 708365; Cyp4f6.
DR   VEuPathDB; HostDB:ENSRNOG00000043233; -.
DR   eggNOG; KOG0157; Eukaryota.
DR   InParanoid; P51871; -.
DR   OMA; SFYDNCC; -.
DR   OrthoDB; 1247045at2759; -.
DR   PhylomeDB; P51871; -.
DR   TreeFam; TF105088; -.
DR   PRO; PR:P51871; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000043233; Expressed in liver and 19 other tissues.
DR   ExpressionAtlas; P51871; baseline and differential.
DR   Genevisible; P51871; RN.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070330; F:aromatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; TAS:RGD.
DR   GO; GO:0006691; P:leukotriene metabolic process; IMP:RGD.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00465; EP450IV.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..537
FT                   /note="Cytochrome P450 4F6"
FT                   /id="PRO_0000051854"
FT   BINDING         468
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:P51869"
SQ   SEQUENCE   537 AA;  61541 MW;  4D96D761A2BEA7E9 CRC64;
     MLQLSLSRLG MGSLTASPWH LLLLGGASWI LARILAWIYT FYDNCCRLRC FPQPPKPSWF
     WGHLTLMKNN EEGMQFIAHL GRNFRDIHLS WVGPVYPILR LVHPNVIAPL LQASAAVAPK
     EMTLYGFLKP WLGDGLLMSA GEKWNHHRRL LTPAFHFDIL KSYVKIFNKS VNTMHAKWQR
     LTAKGSARLD MFEHISLMTL DSLQKCIFSF DSNCQESNSE YIAAILELSS LIVKRQRQPF
     LYLDFLYYLT ADGRRFRKAC DVVHNFTDAV IRERRSTLNT QGVDEFLKAR AKTKTLDFID
     VLLLAKDEHG KGLSDVDIRA EADTFMFGGH DTTASALSWI LYNLARHPEY QERCRQEVRE
     LLRDREPEEI EWDDLAQLPF LTMCIKESLR LHPPVLLISR CCSQDIVLPD GRVIPKGNIC
     VISIFGVHHN PSVWPDPEVY NPFRFDPENP QKRSPLAFIP FSAGPRNCIG QTFAMSEIKV
     ALALTLLRFC VLPDDKEPRR KPELILRAEG GLWLRVEPLS TVTSQLPWDL LAHPPTS