CP4Z2_HUMAN
ID CP4Z2_HUMAN Reviewed; 340 AA.
AC Q8N1L4; Q66ZJ5;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=Putative inactive cytochrome P450 family member 4Z2;
GN Name=CYP4Z2P;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Mammary carcinoma;
RX PubMed=15059886; DOI=10.1158/0008-5472.can-03-0849;
RA Rieger M.A., Ebner R., Bell D.R., Kiessling A., Rohayem J., Schmitz M.,
RA Temme A., Rieber E.P., Weigle B.;
RT "Identification of a novel mammary-restricted cytochrome P450, CYP4Z1, with
RT overexpression in breast carcinoma.";
RL Cancer Res. 64:2357-2364(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Lin L., Zheng G., Ke R., Li H., Zhou G., Shen C., Yang S.;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N1L4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N1L4-2; Sequence=VSP_033072;
CC -!- TISSUE SPECIFICITY: Detected at low levels in mammary gland and mammary
CC carcinoma. {ECO:0000269|PubMed:15059886}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. In contrast to other
CC members of the family, it is shorter at the C-terminus and lacks the
CC heme-binding sites. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY262057; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AY696295; AAU10524.1; -; mRNA.
DR EMBL; AK097373; BAC05026.1; -; mRNA.
DR AlphaFoldDB; Q8N1L4; -.
DR SMR; Q8N1L4; -.
DR IntAct; Q8N1L4; 1.
DR GlyGen; Q8N1L4; 1 site, 1 O-linked glycan (1 site).
DR BioMuta; HGNC:24426; -.
DR DMDM; 187470849; -.
DR jPOST; Q8N1L4; -.
DR MassIVE; Q8N1L4; -.
DR PeptideAtlas; Q8N1L4; -.
DR PRIDE; Q8N1L4; -.
DR GeneCards; CYP4Z2P; -.
DR HGNC; HGNC:24426; CYP4Z2P.
DR MIM; 618954; gene.
DR neXtProt; NX_Q8N1L4; -.
DR InParanoid; Q8N1L4; -.
DR PathwayCommons; Q8N1L4; -.
DR SignaLink; Q8N1L4; -.
DR Pharos; Q8N1L4; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; Q8N1L4; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR SUPFAM; SSF48264; SSF48264; 1.
PE 5: Uncertain;
KW Alternative splicing; Membrane; Reference proteome; Signal-anchor;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..340
FT /note="Putative inactive cytochrome P450 family member 4Z2"
FT /id="PRO_0000330732"
FT TOPO_DOM 1..9
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 10..30
FT /note="Helical; Signal-anchor for type II membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 31..340
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT VAR_SEQ 293..340
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_033072"
FT CONFLICT 8
FT /note="E -> G (in Ref. 2; AAU10524)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="Q -> R (in Ref. 3; BAC05026)"
FT /evidence="ECO:0000305"
FT CONFLICT 107
FT /note="D -> N (in Ref. 2; AAU10524)"
FT /evidence="ECO:0000305"
FT CONFLICT 173
FT /note="Q -> H (in Ref. 2; AAU10524)"
FT /evidence="ECO:0000305"
FT CONFLICT 189
FT /note="D -> H (in Ref. 2; AAU10524)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 340 AA; 40159 MW; 2E6F7C0AACC02EF4 CRC64;
MEPSWLQELM AHPFLLLILL CMSLLLFQVI RLYQRRRWTI RAMHLFPAPP AHWFYGHKES
YPVKEFEVYP ELMEKYPCAV PLWVGPFTMF FNIHDPDYVK ILLKRQDPKS AVSHKILESW
VGRGLVTLDG SKWKKHRQIV KPGFNISILK IFITMMSKSV RMMLNKWEEH IAQNSRLELF
QHVSLMTLDS IMKCAFSHQG SIQLDSTLDS YLKAVFNLSK ISNQRMNNFL HHNDLVFKFS
SQGQIFSKFN QELHQFTEKV IQDRKESLKD KLKQDTTQKR RQDFLDILLS AKSENTKDFS
EADLQAEVKT FMFAGHDTTT TAISWIFYCL AKYPEHQQRC
