ID   CP512_ARATH             Reviewed;         145 AA.
AC   Q5Y750;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Putative sterol 14-demethylase-like protein;
DE   AltName: Full=Cytochrome P450 51A1;
DE   AltName: Full=Cytochrome P450 51G2;
GN   Name=CYP51G2; Synonyms=CYP51A1; OrderedLocusNames=At2g17330;
GN   ORFNames=F5J6.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], DISRUPTION PHENOTYPE, AND TISSUE SPECIFICITY.
RX   PubMed=16040657; DOI=10.1104/pp.105.061598;
RA   Kim H.B., Schaller H., Goh C.H., Kwon M., Choe S., An C.S., Durst F.,
RA   Feldmann K.A., Feyereisen R.;
RT   "Arabidopsis cyp51 mutant shows postembryonic seedling lethality associated
RT   with lack of membrane integrity.";
RL   Plant Physiol. 138:2033-2047(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16169959; DOI=10.1104/pp.105.066639;
RA   O'Brien M., Chantha S.C., Rahier A., Matton D.P.;
RT   "Lipid signaling in plants. Cloning and expression analysis of the
RT   obtusifoliol 14alpha-demethylase from Solanum chacoense Bitt., a
RT   pollination- and fertilization-induced gene with both obtusifoliol and
RT   lanosterol demethylase activity.";
RL   Plant Physiol. 139:734-749(2005).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed specifically in roots.
CC       {ECO:0000269|PubMed:16040657}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:16040657, ECO:0000269|PubMed:16169959}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY666123; AAU44775.1; -; mRNA.
DR   EMBL; CP002685; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; Q5Y750; -.
DR   SMR; Q5Y750; -.
DR   PRIDE; Q5Y750; -.
DR   Araport; AT2G17330; -.
DR   InParanoid; Q5Y750; -.
DR   Proteomes; UP000006548; Chromosome 2.
DR   ExpressionAtlas; Q5Y750; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:InterPro.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   PRINTS; PR00465; EP450IV.
DR   SUPFAM; SSF48264; SSF48264; 1.
PE   5: Uncertain;
KW   Heme; Iron; Membrane; Metal-binding; Methyltransferase; Reference proteome;
KW   Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..145
FT                   /note="Putative sterol 14-demethylase-like protein"
FT                   /id="PRO_0000413011"
FT   TRANSMEM        5..25
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   145 AA;  16568 MW;  ED196F6B09A4BB3C CRC64;
     MDWDYYTLLK TSVAIIIVFV VAKLITSSKS KKKTSVVPLP PVLQAWPPFI GSLIRFMKGP
     IVLLREEYPK LGSVFTVKLL HKNITFLIGP EVSSHFFNAY ESELSQKEIY KFNVPTFGPG
     VVFDVDYPVR MEQFRFFSSA LKVNN