CP6J1_BLAGE
ID CP6J1_BLAGE Reviewed; 501 AA.
AC Q964R1;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Cytochrome P450 6j1;
DE EC=1.14.-.-;
DE AltName: Full=CYPVIJ1;
GN Name=CYP6J1;
OS Blattella germanica (German cockroach) (Blatta germanica).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae;
OC Blattellinae; Blattella.
OX NCBI_TaxID=6973;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=11422508; DOI=10.1046/j.1365-2583.2001.00247.x;
RA Wen Z., Scott J.G.;
RT "Cloning of two novel P450 cDNAs from German cockroaches, Blattella
RT germanica (L.): CYP6K1 and CYP6J1.";
RL Insect Mol. Biol. 10:131-137(2001).
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}. Microsome membrane
CC {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AF281325; AAK57913.1; -; mRNA.
DR AlphaFoldDB; Q964R1; -.
DR SMR; Q964R1; -.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002402; Cyt_P450_E_grp-II.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00464; EP450II.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW Monooxygenase; Oxidoreductase.
FT CHAIN 1..501
FT /note="Cytochrome P450 6j1"
FT /id="PRO_0000051885"
FT BINDING 444
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 501 AA; 57918 MW; 265E97926D9CFE0E CRC64;
MFEFGSIIVT VIAVFITIPI CLYLFLTRHF NFWKKRGVIY VRPLPFFGNL KDVLLQKKYI
GYYLKDIYEE NINKPYVGIF AFDQPALLVN DLEIVKNILV KDSRNFIDRM VKVDESLSPL
NANAIFALRG QKWKHVRTSL TPTFTTGKMK NMFYLVDKCG QQLVLFIEKF AKAENPVAVK
DAVERFTMDV TAMCAFGIEC NSLQDPKAEF SNLLHRIFQL SFTSAVANLA TFFAPWVQNF
FRLKLMDSEI EDRIRDIVWR AVHLREKTGE KRNDLLDYLM ELRTSETSKL DGDDFVAQAF
GFLVAGFHTS SMTLTFALYE LSVHQDIQTT ARTEIKDVLE HHKKKVTYYS IKDMKYLDMV
VNETLRKYPA IPFLDRRCQE DYPLTQDLML PAGTGVYIPV YALHHDSKYF PSPAKFDPER
FSEKNKQNIP HFAYMPFGEG PRNCIGMRFG SMQVKAALIH ILSNFEVSPC KETRIPLIID
PKPFNLMALG GVYLNITKFN N