ID   CP6K1_BLAGE             Reviewed;         524 AA.
AC   Q964R0;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Cytochrome P450 6k1;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPVIK1;
GN   Name=CYP6K1;
OS   Blattella germanica (German cockroach) (Blatta germanica).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae;
OC   Blattellinae; Blattella.
OX   NCBI_TaxID=6973;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RX   PubMed=11422508; DOI=10.1046/j.1365-2583.2001.00247.x;
RA   Wen Z., Scott J.G.;
RT   "Cloning of two novel P450 cDNAs from German cockroaches, Blattella
RT   germanica (L.): CYP6K1 and CYP6J1.";
RL   Insect Mol. Biol. 10:131-137(2001).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Peripheral membrane protein {ECO:0000305}. Microsome membrane
CC       {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC   -!- DEVELOPMENTAL STAGE: Detected in the eggs and stronger expression in
CC       later instars. The strongest signals were detected in the fifth and
CC       sixth instars as well as in adults. {ECO:0000269|PubMed:11422508}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AF281328; AAK57914.1; -; mRNA.
DR   AlphaFoldDB; Q964R0; -.
DR   SMR; Q964R0; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase.
FT   CHAIN           1..524
FT                   /note="Cytochrome P450 6k1"
FT                   /id="PRO_0000051886"
FT   BINDING         464
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   524 AA;  59619 MW;  D436D3B130E6BC00 CRC64;
     MVTITGCALC DALVILATLI VAAYLYYAVR FTYWKRKGVV NPKPLPVFGN FLPSVLQKRS
     PGQILWDIYK AAEAPFVGFY IFARPAILIK DPNIIKHVLV KDFNAFSDRH ASAAESDTLG
     SQNLFTLNGA PWKYLRVKLS PTFTSGRMKK MYPLVESCAK QLQDYLKENC NTKAIEVKET
     TAKYATDVIS TCAFGIESNS LKDPNAEFRE FGRKIFEFTR YRTFEVMALF FSPGLVKFLN
     GNFFTKETTE FLRKVFWDTI NFRESNKISR DDFMDLLIQL KNKGTIDNED GEVTEKVDKI
     DKDSHLFEFT GDNLVSQPAL FFTAGFETNA TTLSFTLYEL SLQPDLQNRL RSEIAGVMKT
     SNGKPTYEDV FGMPYLHMVV SETLRKYPPL PLLDRVCLQD YKVPGTDLII ERDTPVFIAL
     LGLHRDPQYY PNPERYDPER FSEENKRQRK AYTYLPFGEG PHNCIGLRFG YMAVKTALVH
     MLAEFEVKPC KDTPIPLELS TRSSVLATTS GIPLTFVKST AQVS