CP6V1_DROME
ID CP6V1_DROME Reviewed; 520 AA.
AC Q9VRB3; A9UNF2;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Probable cytochrome P450 6v1;
DE EC=1.14.-.-;
DE AltName: Full=CYPVIV1;
GN Name=Cyp6v1; ORFNames=CG1829;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Ovary;
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in the metabolism of insect hormones and in
CC the breakdown of synthetic insecticides. {ECO:0000250}.
CC -!- COFACTOR:
CC Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Peripheral membrane protein {ECO:0000305}. Microsome membrane
CC {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR EMBL; AE014298; AAF50889.1; -; Genomic_DNA.
DR EMBL; BT031316; ABY21729.1; -; mRNA.
DR RefSeq; NP_001285499.1; NM_001298570.1.
DR RefSeq; NP_001285500.1; NM_001298571.1.
DR RefSeq; NP_608403.1; NM_134559.3.
DR AlphaFoldDB; Q9VRB3; -.
DR SMR; Q9VRB3; -.
DR BioGRID; 59344; 5.
DR DIP; DIP-19087N; -.
DR IntAct; Q9VRB3; 2.
DR STRING; 7227.FBpp0076968; -.
DR PaxDb; Q9VRB3; -.
DR DNASU; 33056; -.
DR EnsemblMetazoa; FBtr0077276; FBpp0076968; FBgn0031126.
DR EnsemblMetazoa; FBtr0344467; FBpp0310838; FBgn0031126.
DR EnsemblMetazoa; FBtr0345967; FBpp0311867; FBgn0031126.
DR GeneID; 33056; -.
DR KEGG; dme:Dmel_CG1829; -.
DR UCSC; CG1829-RA; d. melanogaster.
DR CTD; 33056; -.
DR FlyBase; FBgn0031126; Cyp6v1.
DR VEuPathDB; VectorBase:FBgn0031126; -.
DR eggNOG; KOG0158; Eukaryota.
DR HOGENOM; CLU_001570_5_2_1; -.
DR InParanoid; Q9VRB3; -.
DR OMA; KFVQPTH; -.
DR OrthoDB; 467733at2759; -.
DR PhylomeDB; Q9VRB3; -.
DR SignaLink; Q9VRB3; -.
DR BioGRID-ORCS; 33056; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 33056; -.
DR PRO; PR:Q9VRB3; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0031126; Expressed in saliva-secreting gland and 25 other tissues.
DR ExpressionAtlas; Q9VRB3; baseline and differential.
DR Genevisible; Q9VRB3; DM.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR GO; GO:0046701; P:insecticide catabolic process; IBA:GO_Central.
DR GO; GO:0046680; P:response to DDT; IBA:GO_Central.
DR Gene3D; 1.10.630.10; -; 1.
DR InterPro; IPR001128; Cyt_P450.
DR InterPro; IPR017972; Cyt_P450_CS.
DR InterPro; IPR002401; Cyt_P450_E_grp-I.
DR InterPro; IPR036396; Cyt_P450_sf.
DR Pfam; PF00067; p450; 1.
DR PRINTS; PR00463; EP450I.
DR PRINTS; PR00385; P450.
DR SUPFAM; SSF48264; SSF48264; 1.
DR PROSITE; PS00086; CYTOCHROME_P450; 1.
PE 2: Evidence at transcript level;
KW Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW Monooxygenase; Oxidoreductase; Reference proteome.
FT CHAIN 1..520
FT /note="Probable cytochrome P450 6v1"
FT /id="PRO_0000051891"
FT BINDING 465
FT /ligand="heme"
FT /ligand_id="ChEBI:CHEBI:30413"
FT /ligand_part="Fe"
FT /ligand_part_id="ChEBI:CHEBI:18248"
FT /note="axial binding residue"
FT /evidence="ECO:0000250"
SQ SEQUENCE 520 AA; 60763 MW; 36D1F9E4308A974B CRC64;
MVYSTNILLA IVTILTGVFI WSRRTYVYWQ RRRVKFVQPT HLLGNLSRVL RLEESFALQL
RRFYFDERFR NEPVVGIYLF HQPALLIRDL QLVRTVLVED FVSFSNRFAK CDGRSDKMGA
LSLFLAKQPE WREIRTRLAP AFAGAKLKQM FSLMEEIGCD LEWYLKRLTR DLRRGDAERG
AIVSIKDVCD LYNTDMIASI AFGLRSYSLR NTQSEIGSHC QDLFRPNVRR IIDLFVIFYL
PKLVPLLRPK LFTEPHAEFL RRVIQLVIEE RERGGDLRND LIEMLLTLKK EADLQQDKSH
FTHHRDFLAA QAASFEVAGI ETCSASMSFA LYELAKQPLM QSRLRREIRE AFASNPNGRL
TYEAVARMEF LDMVVEETLR KYPIVPLLER ECTPINKKRF YSLRPHAECY TRRGMPVFIS
NLAIHHDPKY WPDPDRFDPE RFSAANKALQ APMSYMPFGA GPRNCIGMQI GLLQIKLGLV
YFLHQHRVEI CDRTVERIQF DAKFALLASE QRIYLKVDCL
