ID   CP77_CWPXB              Reviewed;         668 AA.
AC   Q8QN36;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   23-FEB-2022, entry version 75.
DE   RecName: Full=Ankyrin repeat domain-containing protein CP77;
DE   AltName: Full=Host range protein 1;
GN   Name=CP77; OrderedLocusNames=CPXV025;
OS   Cowpox virus (strain Brighton Red) (CPV).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=265872;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9685; Felis catus (Cat) (Felis silvestris catus).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
OH   NCBI_TaxID=29092; Microtus agrestis (Short-tailed field vole).
OH   NCBI_TaxID=10090; Mus musculus (Mouse).
OH   NCBI_TaxID=447135; Myodes glareolus (Bank vole) (Clethrionomys glareolus).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Dietrich F.S., Ray C.A., Sharma D.A., Allen A., Pickup D.J.;
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND INTERACTION WITH HOST RELA AND SKP1.
RX   PubMed=19211746; DOI=10.1128/jvi.01835-08;
RA   Chang S.J., Hsiao J.C., Sonnberg S., Chiang C.T., Yang M.H., Tzou D.L.,
RA   Mercer A.A., Chang W.;
RT   "Poxvirus host range protein CP77 contains an F-box-like domain that is
RT   necessary to suppress NF-kappaB activation by tumor necrosis factor alpha
RT   but is independent of its host range function.";
RL   J. Virol. 83:4140-4152(2009).
CC   -!- FUNCTION: Substrate-specific adapter of SKP1-containing E3 ubiquitin-
CC       protein ligases which mediate the ubiquitination and subsequent
CC       proteasomal degradation of host target proteins. Prevents activation
CC       and subsequent nuclear localization of NF-kappa-B in infected cells, by
CC       targeting NF-kappa-B RELA subunit to the SCF E3 ligase complex.
CC       {ECO:0000269|PubMed:19211746}.
CC   -!- SUBUNIT: Interacts (via N-terminus) with host RELA. Interacts (via
CC       PRANC/F-box-like domain) with the SKP1 component of the host SCF
CC       ubiquitin ligase complex. {ECO:0000269|PubMed:19211746}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF482758; AAM13472.1; -; Genomic_DNA.
DR   PIR; A29887; HRVZCP.
DR   RefSeq; NP_619814.1; NC_003663.2.
DR   SMR; Q8QN36; -.
DR   DNASU; 1485900; -.
DR   GeneID; 1485900; -.
DR   KEGG; vg:1485900; -.
DR   Proteomes; UP000152733; Genome.
DR   GO; GO:0060153; P:modulation by virus of host cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0039648; P:modulation by virus of host protein ubiquitination; IEA:UniProtKB-KW.
DR   GO; GO:0039649; P:modulation by virus of host ubiquitin-protein ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0039644; P:suppression by virus of host NF-kappaB cascade; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.20; -; 3.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR018272; PRANC_domain.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF09372; PRANC; 1.
DR   SMART; SM00248; ANK; 7.
DR   SUPFAM; SSF48403; SSF48403; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 2.
DR   PROSITE; PS50088; ANK_REPEAT; 1.
PE   1: Evidence at protein level;
KW   ANK repeat; Host-virus interaction; Inhibition of host NF-kappa-B by virus;
KW   Modulation of host cell cycle by virus;
KW   Modulation of host E3 ubiquitin ligases by virus;
KW   Modulation of host ubiquitin pathway by virus; Repeat;
KW   Ubl conjugation pathway.
FT   CHAIN           1..668
FT                   /note="Ankyrin repeat domain-containing protein CP77"
FT                   /id="PRO_0000396621"
FT   REPEAT          31..64
FT                   /note="ANK 1"
FT   REPEAT          101..131
FT                   /note="ANK 2"
FT   REPEAT          135..166
FT                   /note="ANK 3"
FT   REPEAT          199..231
FT                   /note="ANK 4"
FT   REPEAT          235..266
FT                   /note="ANK 5"
FT   REPEAT          277..311
FT                   /note="ANK 6"
FT   REPEAT          334..368
FT                   /note="ANK 7"
FT   REPEAT          458..487
FT                   /note="ANK 8"
FT   REPEAT          491..521
FT                   /note="ANK 9"
FT   REGION          586..666
FT                   /note="PRANC/F-box-like"
SQ   SEQUENCE   668 AA;  77235 MW;  3C7031A078F1586D CRC64;
     MFDYLENEEV ALDELKQMLR DRDPNDTRNQ FKNNALHAYL FNEHCNNVEV VKLLLDSGTN
     PLHKNWRQLT PLGEYTNSRH GKVNKDIAMV LLEATGYSNI NDFNIFTYMK SKNVDIDLIK
     VLVEHGFDFS VKCEKHHSVI ENYVMTDDPV PEIIDLFIEN GCSVIYEDED DEYGYAYEEY
     HSQNDDYQPR NCGTVLHLYI ISHLYSESDS RSCVNPEVVK CLINHGINPS SIDKNYCTAL
     QYYIKSSHID IDIVKLLMKG IDNTAYSYID DLTCCTRGIM ADYLNSDYRY NKDVDLDLVK
     LFLENGKPHG IMCSIVPLWR NDKETISLIL KTMNSDVLQH ILIEYITFSD IDISLVEYML
     EYGAVVNKEA IHGYFKNINI DSYTMKYLLK KEGGDAVNHL DDGEIPIGHL CKSNYGRYNF
     YTDTYRQGFR DMSYACPILS TINICLPYLK DINMIDKRGE TLLHKAVRYN KQSLVSLLLE
     SGSDVNIRSN NGYTCIAIAI NESRNIELLN MLLCHKPTLD CVIDSLREIS NIVDNAYAIK
     QCIRYAMIID DCISSKIPES ISKHYNDYID ICNQELNEMK KIIVGGNTMF SLIFTDHGAK
     IIHRYANNPE LRAYYESKQN KIYVEVYDII SNAIVKHNKI HKNIESVDDN TYISNLPYTI
     KYKIFEQQ