ID   CP91_CONRE              Reviewed;          90 AA.
AC   Q8I6V7;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Conotoxin Rg9.1 {ECO:0000305};
DE   Flags: Precursor;
OS   Conus regius (Crown cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=101314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RA   Braga M.C.V., Freitas J.C., Yamane T., Radis-Baptista G.;
RT   "A P-superfamily toxin encoded from Conus regius cDNA.";
RL   Submitted (AUG-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable neurotoxin that inhibits ion channels.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|Ref.1}.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin P superfamily. {ECO:0000305}.
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DR   EMBL; AY144359; AAN06008.1; -; mRNA.
DR   AlphaFoldDB; Q8I6V7; -.
DR   SMR; Q8I6V7; -.
DR   TCDB; 8.B.22.1.2; the p-conotoxin cystine knot (p-cck) family.
DR   ConoServer; 1509; Rg9.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR010012; Toxin_11.
DR   Pfam; PF07473; Toxin_11; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..60
FT                   /evidence="ECO:0000305|Ref.1"
FT                   /id="PRO_0000035009"
FT   PEPTIDE         61..90
FT                   /note="Conotoxin Rg9.1"
FT                   /evidence="ECO:0000305|Ref.1"
FT                   /id="PRO_0000035010"
FT   DISULFID        58..71
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        62..73
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        67..80
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
SQ   SEQUENCE   90 AA;  10091 MW;  FC180B2F08EAE730 CRC64;
     MHLSLARSAV LILLLLFALG NFVGVQPGQI TRDADHGINL RSLRKQMSRS PLVKGAFCGQ
     ACSSVKCPKK CFCHPEEKVC YREMRTKERD