ID   CP92_CONBE              Reviewed;          27 AA.
AC   P81727;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2002, sequence version 1.
DT   03-AUG-2022, entry version 53.
DE   RecName: Full=Conotoxin Bt9.2 {ECO:0000305};
DE   AltName: Full=Conotoxin BeTXIIb {ECO:0000303|PubMed:10591037};
OS   Conus betulinus (Beech cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Dendroconus.
OX   NCBI_TaxID=89764;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, HYDROXYLATION AT PRO-13, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=10591037;
RA   Chen J.-S., Fan C.-X., Hu K.-P., Wei K.-H., Zhong M.-N.;
RT   "Studies on conotoxins of Conus betulinus.";
RL   J. Nat. Toxins 8:341-349(1999).
CC   -!- FUNCTION: Probable neurotoxin that inhibits ion channels.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10591037}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:10591037}.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2664.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:10591037};
CC   -!- SIMILARITY: Belongs to the conotoxin P superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P81727; -.
DR   ConoServer; 1515; BeTXIIb.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Disulfide bond; Hydroxylation;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..27
FT                   /note="Conotoxin Bt9.2"
FT                   /evidence="ECO:0000269|PubMed:10591037"
FT                   /id="PRO_0000044490"
FT   MOD_RES         13
FT                   /note="4-hydroxyproline"
FT                   /evidence="ECO:0000269|PubMed:10591037"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        6..19
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        12..24
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
SQ   SEQUENCE   27 AA;  2651 MW;  60F0500514C7F1BA CRC64;
     GCGGVCAYGE SCPSSCNTCY SAQCTAQ