ID   CP94_CONIM              Reviewed;          92 AA.
AC   A0A125S9F6;
DT   07-OCT-2020, integrated into UniProtKB/Swiss-Prot.
DT   13-APR-2016, sequence version 1.
DT   03-AUG-2022, entry version 11.
DE   RecName: Full=Conotoxin Im9.4 {ECO:0000305};
DE   AltName: Full=Conopeptide im022 {ECO:0000303|PubMed:30893765, ECO:0000312|EMBL:AME17680.1};
DE   Flags: Precursor;
OS   Conus imperialis (Imperial cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Stephanoconus.
OX   NCBI_TaxID=35631;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION BY MASS SPECTROMETRY, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=30893765; DOI=10.3390/md17030177;
RA   Jin A.H., Dutertre S., Dutt M., Lavergne V., Jones A., Lewis R.J.,
RA   Alewood P.F.;
RT   "Transcriptomic-proteomic correlation in the predation-evoked venom of the
RT   cone snail, Conus imperialis.";
RL   Mar. Drugs 17:0-0(2019).
CC   -!- FUNCTION: Probable neurotoxin that inhibits ion channels.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30893765}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:30893765}.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin P superfamily. {ECO:0000305}.
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DR   EMBL; KT377416; AME17680.1; -; mRNA.
DR   AlphaFoldDB; A0A125S9F6; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Disulfide bond; Ion channel impairing toxin; Neurotoxin;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   PROPEP          21..62
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000451006"
FT   PEPTIDE         63..90
FT                   /note="Conotoxin Im9.4"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5007179731"
FT   MOD_RES         90
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        65..79
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        69..81
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        75..87
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
SQ   SEQUENCE   92 AA;  10059 MW;  318EB7174E7A146F CRC64;
     MHRSLAGSAV LMLLLLFALG NFVGVQPGLV TRDADNGQLM DNRRNLRLER KTMSLFKSLD
     KRADCSTYCF GMGICQSGCY CGPGHACMPN GR