ID   CP9A_CONLT              Reviewed;          73 AA.
AC   Q2I2P4; Q2I2P5; Q2I2P6;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Conotoxin Lt9a {ECO:0000305};
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE, IDENTIFICATION BY
RP   MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom, and Venom duct;
RX   PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA   Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA   Dong M., Chen S., Xu A.;
RT   "Diversity and evolution of conotoxins based on gene expression profiling
RT   of Conus litteratus.";
RL   Genomics 88:809-819(2006).
CC   -!- FUNCTION: Probable neurotoxin that inhibits ion channels.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16908117}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC       {ECO:0000305|PubMed:16908117}.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C). {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the conotoxin P superfamily. {ECO:0000305}.
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DR   EMBL; DQ345386; ABC74994.1; -; mRNA.
DR   EMBL; DQ345387; ABC74995.1; -; mRNA.
DR   EMBL; DQ345388; ABC74996.1; -; mRNA.
DR   AlphaFoldDB; Q2I2P4; -.
DR   TCDB; 8.B.22.1.4; the p-conotoxin cystine knot (p-cck) family.
DR   ConoServer; 1174; Lt9a variant 2 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cleavage on pair of basic residues; Direct protein sequencing;
KW   Disulfide bond; Ion channel impairing toxin; Neurotoxin; Secreted; Signal;
KW   Toxin.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   PROPEP          24..40
FT                   /evidence="ECO:0000305|PubMed:16908117"
FT                   /id="PRO_0000315520"
FT   PEPTIDE         43..73
FT                   /note="Conotoxin Lt9a"
FT                   /evidence="ECO:0000305|PubMed:16908117"
FT                   /id="PRO_0000315521"
FT   DISULFID        48..62
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        53..64
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        59..69
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   VARIANT         44
FT                   /note="S -> R"
FT   VARIANT         55
FT                   /note="T -> A"
SQ   SEQUENCE   73 AA;  7825 MW;  D3EA29F1AF799A47 CRC64;
     MTLTKSAVLI LVLLLAFDNF ADVQPGLITM GGGRLSNLLS KRVSIWFCAS RTCSTPADCN
     PCTCESGVCV DWL