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CP9B1_DROME
ID   CP9B1_DROME             Reviewed;         505 AA.
AC   Q9V4I0; Q24122;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 154.
DE   RecName: Full=Cytochrome P450 9b1;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPIXB1;
GN   Name=Cyp9b1; ORFNames=CG4485;
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley;
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA   Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA   Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA   An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA   Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA   Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA   Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA   Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA   Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA   Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA   Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA   Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA   Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA   Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA   Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA   Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA   Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA   McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA   Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA   Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA   Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA   Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA   Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA   Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA   Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA   Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA   Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA   Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA   Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley;
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA   Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT   review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE OF 326-444.
RC   STRAIN=Haag-79, and Hikone-R;
RX   PubMed=8676871; DOI=10.1007/bf02172519;
RA   Dunkov B.C., Rodriguez-Arnaiz R., Pittendrigh B., ffrench-Constant R.H.,
RA   Feyereisen R.;
RT   "Cytochrome P450 gene clusters in Drosophila melanogaster.";
RL   Mol. Gen. Genet. 251:290-297(1996).
CC   -!- FUNCTION: May be involved in the metabolism of insect hormones and in
CC       the breakdown of synthetic insecticides. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Peripheral membrane protein {ECO:0000305}. Microsome membrane
CC       {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AE013599; AAF59291.1; -; Genomic_DNA.
DR   EMBL; U34324; AAA80658.1; -; mRNA.
DR   PIR; S70620; S70620.
DR   RefSeq; NP_523645.1; NM_078921.4.
DR   AlphaFoldDB; Q9V4I0; -.
DR   SMR; Q9V4I0; -.
DR   STRING; 7227.FBpp0088127; -.
DR   PaxDb; Q9V4I0; -.
DR   DNASU; 35634; -.
DR   EnsemblMetazoa; FBtr0089056; FBpp0088127; FBgn0015038.
DR   GeneID; 35634; -.
DR   KEGG; dme:Dmel_CG4485; -.
DR   CTD; 35634; -.
DR   FlyBase; FBgn0015038; Cyp9b1.
DR   VEuPathDB; VectorBase:FBgn0015038; -.
DR   eggNOG; KOG0158; Eukaryota.
DR   GeneTree; ENSGT00940000165057; -.
DR   HOGENOM; CLU_001570_5_2_1; -.
DR   InParanoid; Q9V4I0; -.
DR   OMA; AGENAFE; -.
DR   OrthoDB; 467733at2759; -.
DR   PhylomeDB; Q9V4I0; -.
DR   BioGRID-ORCS; 35634; 0 hits in 3 CRISPR screens.
DR   GenomeRNAi; 35634; -.
DR   PRO; PR:Q9V4I0; -.
DR   Proteomes; UP000000803; Chromosome 2R.
DR   Bgee; FBgn0015038; Expressed in mouthpart and 11 other tissues.
DR   ExpressionAtlas; Q9V4I0; baseline and differential.
DR   Genevisible; Q9V4I0; DM.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002403; Cyt_P450_E_grp-IV.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00465; EP450IV.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase; Reference proteome.
FT   CHAIN           1..505
FT                   /note="Cytochrome P450 9b1"
FT                   /id="PRO_0000051916"
FT   BINDING         449
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        345
FT                   /note="P -> L (in Ref. 1; AAA80658)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   505 AA;  58736 MW;  0C628FAC35174E05 CRC64;
     MSFVEICLVL ATIGLLLFKW STGTFKAFEG RNLYFEKPYP FLGNMAASAL QKASFQKQIS
     EFYNRTRHHK LVGLFNLRTP MIQINDPQLI KKICVKDFDH FPNHQTLNIP NERLVNDMLN
     VMRDQHWRNM RSVLTPVFTS AKMRNMFTLM NESFAQCLEH LKSSQPIAAG ENAFELDMKV
     LCNKLSNDVI ATTAFGLKVN SFDDPENEFH TIGKTLAFSR GLPFLKFMMC LLAPKVFNFF
     KLTIFDSTNV EYFVRLVVDA MQYREKHNIT RPDMIQLLME AKKESKDNWT DDEIVAQCFI
     FFFAAFENNS NLICTTAYEL LRNLDIQERL YEEVKETQEA LKGAPLTYDA AQEMTYMDMV
     ISESLRKWTL SAAADRLCAK DYTLTDDEGT KLFEFKAGDN INIPICGLHW DERFFPQPQR
     FDPERFSERR KKDLIPYTYL PFGVGPRSCI GNRYAVMQAK GMLYNLMLNY KIEASPRTTR
     DMWESARGFN IIPTTGFWMQ LVSRK
 
 
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