ID   CP9E2_BLAGE             Reviewed;         533 AA.
AC   Q964T2;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Cytochrome P450 9e2;
DE            EC=1.14.-.-;
DE   AltName: Full=CYPIXE2;
GN   Name=CYP9E2;
OS   Blattella germanica (German cockroach) (Blatta germanica).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Polyneoptera; Dictyoptera; Blattodea; Blaberoidea; Ectobiidae;
OC   Blattellinae; Blattella.
OX   NCBI_TaxID=6973;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RX   PubMed=11470532; DOI=10.1016/s0378-1119(01)00529-7;
RA   Wen Z., Horak C.E., Scott J.G.;
RT   "CYP9E2, CYP4C21 and related pseudogenes from German cockroaches, Blattella
RT   germanica: implications for molecular evolution, expression studies and
RT   nomenclature of P450s.";
RL   Gene 272:257-266(2001).
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC       Peripheral membrane protein {ECO:0000305}. Microsome membrane
CC       {ECO:0000305}; Peripheral membrane protein {ECO:0000305}.
CC   -!- INDUCTION: Expressed at all life stages. {ECO:0000269|PubMed:11470532}.
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; AF275640; AAK69410.1; -; mRNA.
DR   AlphaFoldDB; Q964T2; -.
DR   SMR; Q964T2; -.
DR   PRIDE; Q964T2; -.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   2: Evidence at transcript level;
KW   Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome;
KW   Monooxygenase; Oxidoreductase.
FT   CHAIN           1..533
FT                   /note="Cytochrome P450 9e2"
FT                   /id="PRO_0000051919"
FT   BINDING         475
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   533 AA;  61482 MW;  F9D9FDFDA026C9DD CRC64;
     MMSLESLWLW TFAISFIVLI AYLIGTWNHD FFSKRNIPSL KTVPFLGNMG PLVLRKASFA
     EHSQNIYNRL KGYKYGGMFE FMNPVLVLRD PELIKMVTVK DFEYFLDHRA PISEEAEPMF
     GKNLFNLRGH RWKEMRSTLS PAFTSSKMKN MFVLVSECGK QLGEFLMECS RDKNKKTEGC
     KIEREGDLLT VELKDLYTRY TNDVIATSAF GIGCDSLKNP KNEFFQMGKD VTNFGGIRQF
     IFLGYLFSPR LMKYLNLKFL SSKATEFFRF LVHNTMDTRK TKGIIRPDMI HLLMQAKEGT
     LKSEENGETN GKIASKPKWD DDDLTAQAVL FFFAGFDTAS TLLCFMSHLL ATNPDVQNRL
     QDEIDQSLEE NDGKLTYEAI HSMKYLDMVV SESLRLYPPA IFTDRKCVKN YRLPMEPSYT
     LEPGDAVWIP IYAIHHDPKY YPNPEKFDPE RFSDENKDNI KPFTYLPFGS GPRNCIGNRF
     ALMESKIALV HLLCRFNLKV VSKTPIPIKI TKKGFNMTVD GGFWLGLEER TNQ