ID   CP9_CONAA               Reviewed;          27 AA.
AC   P83390;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Conotoxin;
OS   Conus amadis (Amadis cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Leptoconus.
OX   NCBI_TaxID=198732;
RN   [1]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Venom;
RA   Saminathan R., Gopalakrishnakone P.;
RL   Submitted (JUN-2002) to UniProtKB.
CC   -!- FUNCTION: Probable neurotoxin that inhibits ion channels.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.1}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct. {ECO:0000305|Ref.1}.
CC   -!- DOMAIN: The cysteine framework is IX (C-C-C-C-C-C). {ECO:0000305}.
CC   -!- MASS SPECTROMETRY: Mass=2975.71; Method=Electrospray;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- MASS SPECTROMETRY: Mass=2975.5002; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.1};
CC   -!- SIMILARITY: Belongs to the conotoxin P superfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P83390; -.
DR   SMR; P83390; -.
DR   TCDB; 8.B.22.1.3; the p-conotoxin cystine knot (p-cck) family.
DR   ConoServer; 1389; Conotoxin.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0099106; F:ion channel regulator activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR010012; Toxin_11.
DR   Pfam; PF07473; Toxin_11; 1.
PE   1: Evidence at protein level;
KW   Amidation; Direct protein sequencing; Disulfide bond;
KW   Ion channel impairing toxin; Neurotoxin; Secreted; Toxin.
FT   PEPTIDE         1..27
FT                   /note="Conotoxin"
FT                   /evidence="ECO:0000269|Ref.1"
FT                   /id="PRO_0000044489"
FT   MOD_RES         27
FT                   /note="Asparagine amide"
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        2..16
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        6..18
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
FT   DISULFID        12..23
FT                   /evidence="ECO:0000250|UniProtKB:Q9GU57"
SQ   SEQUENCE   27 AA;  2981 MW;  C038DED3E32913FA CRC64;
     SCNNSCQQHS QCASHCVCLL NKCRTVN