ID   CPB1_CAEBR              Reviewed;         585 AA.
AC   Q6E3D0; A8XAG1; Q61IP6;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Cytoplasmic polyadenylation element-binding protein 1;
GN   Name=cpb-1; ORFNames=CBG10126;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=15231741; DOI=10.1101/gr.2639304;
RA   Cho S., Jin S.W., Cohen A., Ellis R.E.;
RT   "A phylogeny of Caenorhabditis reveals frequent loss of introns during
RT   nematode evolution.";
RL   Genome Res. 14:1207-1220(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC       binds to and regulates the translation of specific mRNAs. Essential for
CC       progression through meiosis. Involved in spermatogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with fbf-1. {ECO:0000250}.
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DR   EMBL; AY589642; AAT72426.1; -; Genomic_DNA.
DR   EMBL; AY589592; AAT72409.1; -; mRNA.
DR   EMBL; HE601459; CAP29629.3; -; Genomic_DNA.
DR   AlphaFoldDB; Q6E3D0; -.
DR   SMR; Q6E3D0; -.
DR   STRING; 6238.CBG10126; -.
DR   EnsemblMetazoa; CBG10126.1; CBG10126.1; WBGene00031597.
DR   WormBase; CBG10126; CBP37601; WBGene00031597; Cbr-cpb-1.
DR   eggNOG; KOG0129; Eukaryota.
DR   HOGENOM; CLU_035644_0_0_1; -.
DR   InParanoid; Q6E3D0; -.
DR   OMA; KHNYAPY; -.
DR   OrthoDB; 1075356at2759; -.
DR   Proteomes; UP000008549; Chromosome III.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0008135; F:translation factor activity, RNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:EnsemblMetazoa.
DR   GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 4.10.640.40; -; 1.
DR   InterPro; IPR032296; CEBP_ZZ.
DR   InterPro; IPR038446; CEBP_ZZ_sf.
DR   InterPro; IPR034819; CPEB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12566; PTHR12566; 1.
DR   Pfam; PF16366; CEBP_ZZ; 1.
DR   Pfam; PF16367; RRM_7; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Reference proteome; Repeat;
KW   RNA-binding; Spermatogenesis.
FT   CHAIN           1..585
FT                   /note="Cytoplasmic polyadenylation element-binding protein
FT                   1"
FT                   /id="PRO_0000081508"
FT   DOMAIN          251..356
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          373..444
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          513..533
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   585 AA;  65527 MW;  08366D339F59EC3D CRC64;
     MQHQLKACGD VKTSSRAQQN HRRSTAASAK RSVGAGNSFL ATDVTNLEMN SNFMTRKLKK
     NGNGVIGSPL SNGYFGAQLT ANSFNYTPQA NPYSNLDFQM AMGSGDVPSL MGMPVHKPSM
     MLQSDPSMDL TQFTEELQAI QNMPFQPISS SQAALQAFLA ANEAASIGSY GFSKSQMLPS
     NSMRVSGARK NRIVEVKNQN DRLFLVLSDP QASVSTRPTL VPLTRPLQSV AQSCLDLTKK
     QPFSTEPLYS RKVFIGGLPI DVPDEEVYVT FGSFGKVLID WPRRPEHNGR ASDMYESEMG
     RRNLRSVSGY VFLVFTHEDS VQDLVNACEF YDGKYYLQLS SPTMQDKAVQ VRPWRLSDID
     YFSEEKVTVD PRRTVFIGGV PRPTRACDLA RSLQDYYGKV SYVGIDIDPE LKYPKGAARV
     TFATAQSFVR AISGRFVQVT HAETNKRVEI KPYVMEDQYC DECEGDLCKH NYAPYYCGDS
     SCLQYYCEGC WDRMHYEMGQ SRADHRPMVR TGDQTRILPR PPHHPAAHHS HQRPQYLLHQ
     DQLDNHHSSR GNSSVISRIV NRNSATMLDH VPGKPFSAIS ASYGY