CPB1_CAEEL
ID CPB1_CAEEL Reviewed; 560 AA.
AC Q03571;
DT 01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 3.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Cytoplasmic polyadenylation element-binding protein 1;
GN Name=cpb-1; ORFNames=C40H1.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=7906398; DOI=10.1038/368032a0;
RA Wilson R., Ainscough R., Anderson K., Baynes C., Berks M., Bonfield J.,
RA Burton J., Connell M., Copsey T., Cooper J., Coulson A., Craxton M.,
RA Dear S., Du Z., Durbin R., Favello A., Fraser A., Fulton L., Gardner A.,
RA Green P., Hawkins T., Hillier L., Jier M., Johnston L., Jones M.,
RA Kershaw J., Kirsten J., Laisster N., Latreille P., Lightning J., Lloyd C.,
RA Mortimore B., O'Callaghan M., Parsons J., Percy C., Rifken L., Roopra A.,
RA Saunders D., Shownkeen R., Sims M., Smaldon N., Smith A., Smith M.,
RA Sonnhammer E., Staden R., Sulston J., Thierry-Mieg J., Thomas K.,
RA Vaudin M., Vaughan K., Waterston R., Watson A., Weinstock L.,
RA Wilkinson-Sproat J., Wohldman P.;
RT "2.2 Mb of contiguous nucleotide sequence from chromosome III of C.
RT elegans.";
RL Nature 368:32-38(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, DEVELOPMENTAL STAGE, AND INTERACTION WITH FBF-1.
RX PubMed=11040214; DOI=10.1101/gad.831700;
RA Luitjens C., Gallegos M., Kraemer B., Kimble J., Wickens M.;
RT "CPEB proteins control two key steps in spermatogenesis in C. elegans.";
RL Genes Dev. 14:2596-2609(2000).
CC -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC binds to and regulates the translation of specific mRNAs. Essential for
CC progression through meiosis. Involved in spermatogenesis.
CC {ECO:0000269|PubMed:11040214}.
CC -!- SUBUNIT: Interacts with fbf-1. {ECO:0000269|PubMed:11040214}.
CC -!- INTERACTION:
CC Q03571; Q9N5M6: fbf-1; NbExp=5; IntAct=EBI-316645, EBI-1569950;
CC -!- DEVELOPMENTAL STAGE: Present in the germline just prior to overt
CC spermatogenesis; once sperm differentiation begins, it disappears.
CC {ECO:0000269|PubMed:11040214}.
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DR EMBL; Z19154; CAA79552.3; -; Genomic_DNA.
DR PIR; S28296; S28296.
DR RefSeq; NP_499051.3; NM_066650.5.
DR AlphaFoldDB; Q03571; -.
DR SMR; Q03571; -.
DR BioGRID; 41508; 3.
DR DIP; DIP-24993N; -.
DR IntAct; Q03571; 2.
DR STRING; 6239.C40H1.1; -.
DR PaxDb; Q03571; -.
DR PRIDE; Q03571; -.
DR EnsemblMetazoa; C40H1.1.1; C40H1.1.1; WBGene00000770.
DR GeneID; 176310; -.
DR KEGG; cel:CELE_C40H1.1; -.
DR UCSC; C40H1.1; c. elegans.
DR CTD; 176310; -.
DR WormBase; C40H1.1; CE43522; WBGene00000770; cpb-1.
DR eggNOG; KOG0129; Eukaryota.
DR GeneTree; ENSGT00940000169843; -.
DR HOGENOM; CLU_035644_0_0_1; -.
DR InParanoid; Q03571; -.
DR OMA; KHNYAPY; -.
DR OrthoDB; 1075356at2759; -.
DR PhylomeDB; Q03571; -.
DR PRO; PR:Q03571; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000770; Expressed in germ line (C elegans) and 3 other tissues.
DR GO; GO:0005737; C:cytoplasm; IDA:WormBase.
DR GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IBA:GO_Central.
DR GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR GO; GO:0008135; F:translation factor activity, RNA binding; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0051321; P:meiotic cell cycle; IMP:WormBase.
DR GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0006417; P:regulation of translation; TAS:WormBase.
DR GO; GO:0007283; P:spermatogenesis; IMP:WormBase.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.640.40; -; 1.
DR InterPro; IPR032296; CEBP_ZZ.
DR InterPro; IPR038446; CEBP_ZZ_sf.
DR InterPro; IPR034819; CPEB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR12566; PTHR12566; 1.
DR Pfam; PF16366; CEBP_ZZ; 1.
DR Pfam; PF16367; RRM_7; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; Reference proteome; Repeat;
KW RNA-binding; Spermatogenesis.
FT CHAIN 1..560
FT /note="Cytoplasmic polyadenylation element-binding protein
FT 1"
FT /id="PRO_0000081509"
FT DOMAIN 246..349
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 366..437
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 560 AA; 63362 MW; FF46A86B9133B709 CRC64;
MQYQLSPSGD FKTSAPVRSS HGHRRSTESK KSGGHGNPYL STDKTNLDIS VSFLTSQAQK
KMRGMSANHG IFDPTEMLTA DDPSNYGYQF LNHATFYNNM DIMQAASGDV PPLMSVNPYK
QSFDINDASA AMNMAQFAHT LNAIQNSSYS MSHYNQAPMQ HFISPNSFHV SYNQRFPHIK
KNATHANRMV EIKKINGHRY MEVTDPQAVS APPEYKRLDG SLMGVSKSCL EASKKRPISA
EPLYSRKVFI GGLPIDVSEE QVWATFGAFG KVLIDWPRRP EHNAERAEQE LKKGSGSRAV
TGYVFLVFTH ERSVQELVNA CEFYEDKYYL QLSSPTMTDK AVQVRPWRLS DIDYFCNDNS
SVDHRRTVFI GGVPRPTRAQ DLARCLEGHY GKVSYVGIDI DPELKYPKGA ARVTFSTSQA
FVRAISGRFV QVNHAENNKR VEIKPYVMEE QYCDECEGRL CKHNYAPYFC GHASCLQYYC
EGCWDRMHIG KNEDNKLEDQ HYPMVRTGDQ TRLLKHLPHR SSGFKPAPVF HPSSQSTTAK
ILAYGDQSQR QFSATPSYSF
