CPB1_CAEJA
ID CPB1_CAEJA Reviewed; 617 AA.
AC Q6E3C7;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 69.
DE RecName: Full=Cytoplasmic polyadenylation element-binding protein 1;
GN Name=cpb-1;
OS Caenorhabditis japonica.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=281687;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=15231741; DOI=10.1101/gr.2639304;
RA Cho S., Jin S.W., Cohen A., Ellis R.E.;
RT "A phylogeny of Caenorhabditis reveals frequent loss of introns during
RT nematode evolution.";
RL Genome Res. 14:1207-1220(2004).
CC -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC binds to and regulates the translation of specific mRNAs. Essential for
CC progression through meiosis. Involved in spermatogenesis (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with fbf-1. {ECO:0000250}.
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DR EMBL; AY589645; AAT72429.1; -; Genomic_DNA.
DR EMBL; AY589595; AAT72412.1; -; mRNA.
DR AlphaFoldDB; Q6E3C7; -.
DR SMR; Q6E3C7; -.
DR STRING; 281687.CJA18184; -.
DR eggNOG; KOG0129; Eukaryota.
DR HOGENOM; CLU_035644_0_0_1; -.
DR InParanoid; Q6E3C7; -.
DR OMA; KHNYAPY; -.
DR Proteomes; UP000005237; Unassembled WGS sequence.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.640.40; -; 1.
DR InterPro; IPR032296; CEBP_ZZ.
DR InterPro; IPR038446; CEBP_ZZ_sf.
DR InterPro; IPR034819; CPEB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR12566; PTHR12566; 1.
DR Pfam; PF16366; CEBP_ZZ; 1.
DR Pfam; PF16367; RRM_7; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 2.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Reference proteome; Repeat;
KW RNA-binding; Spermatogenesis.
FT CHAIN 1..617
FT /note="Cytoplasmic polyadenylation element-binding protein
FT 1"
FT /id="PRO_0000081510"
FT DOMAIN 273..377
FT /note="RRM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT DOMAIN 394..465
FT /note="RRM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 592..617
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..560
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..608
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 617 AA; 67879 MW; F9FF95B1713C6614 CRC64;
MQSQLKACGD APAPSCSLHH RRTISKKPSN GGNSGGGGGG VNSAYLATDV TTLDINAMFQ
SKKMKRHGAG VTAPSTPANY LGASAGAGQA NPAHFNFPSY LNPASFYPNV DLLGGSSEHL
PPLMSVPAYK PTSMLHGFSD AASAMDFAQL TEELNALQNL SASFPNSTPN AFQSLFATDS
PSSFLTSSAV SSHLAKPSPL TANSVRGAGG RKNRMVEVKM INERPVVIVS DPQAASASAR
SQIVHLNRNV LGVLKGLEAS KKRSISAEPL YSRKVFIGGL PIDVTEEEVW ATFGWFGKVL
VDWPRRPEHG GRGDFYEMDM GRRNSRSVSG YVFLVFQDEK AVQELVNACE LYENKYYLQL
SSPTMADKAV QVRAWRLSDI DYFCDENASV DHRRTVFIGG VPRPTRASDL AYCLQQHYGK
VSYVGIDIDP ELKYPKGAAR VTFATAQSFV RAISGRFVQV THADTNKRVE IKPYVMEDQH
CDECQGKLCK HNYAPYFCGD SSCLQYYCEA CWDRMHYAMC DNRADHRPMV RTGDQTRILP
RPPHHSTSHY HHRSTPSHHH NHTHQNVTSS LLEHAPHLQN TSIISRIVNR NNQNNNSANS
TPPQMKQFSA IPTAIGY