ID   CPB1_CAERE              Reviewed;         594 AA.
AC   Q6E3C9;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Cytoplasmic polyadenylation element-binding protein 1;
GN   Name=cpb-1;
OS   Caenorhabditis remanei (Caenorhabditis vulgaris).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=31234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=15231741; DOI=10.1101/gr.2639304;
RA   Cho S., Jin S.W., Cohen A., Ellis R.E.;
RT   "A phylogeny of Caenorhabditis reveals frequent loss of introns during
RT   nematode evolution.";
RL   Genome Res. 14:1207-1220(2004).
CC   -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC       binds to and regulates the translation of specific mRNAs. Essential for
CC       progression through meiosis. Involved in spermatogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with fbf-1. {ECO:0000250}.
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DR   EMBL; AY589643; AAT72427.1; -; Genomic_DNA.
DR   EMBL; AY589593; AAT72410.1; -; mRNA.
DR   AlphaFoldDB; Q6E3C9; -.
DR   SMR; Q6E3C9; -.
DR   STRING; 31234.CRE25597; -.
DR   eggNOG; KOG0129; Eukaryota.
DR   HOGENOM; CLU_035644_0_0_1; -.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR   GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 4.10.640.40; -; 1.
DR   InterPro; IPR032296; CEBP_ZZ.
DR   InterPro; IPR038446; CEBP_ZZ_sf.
DR   InterPro; IPR034819; CPEB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12566; PTHR12566; 1.
DR   Pfam; PF16366; CEBP_ZZ; 1.
DR   Pfam; PF16367; RRM_7; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Repeat; RNA-binding;
KW   Spermatogenesis.
FT   CHAIN           1..594
FT                   /note="Cytoplasmic polyadenylation element-binding protein
FT                   1"
FT                   /id="PRO_0000081511"
FT   DOMAIN          257..364
FT                   /note="RRM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   DOMAIN          381..452
FT                   /note="RRM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..33
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          519..560
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        534..560
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   594 AA;  66135 MW;  48C9FF66C418DC06 CRC64;
     MQHQVKACGD SKSTTRSLQG NRRSGAASLK KPSGNGTFLA TDVTNLDMNS SFLSKKLKRN
     GNPVIGMNIQ SSNAFLGAQL AANNFNFAQQ LNHAALYNNL EFQMAVASGD VPSLMSMPAH
     KPSLSVSSID PSMDMSQFTE ELNAIQNMSY SPMMPSSAAL QSIFAANDSS AISPYMNLQK
     TSLLPTSTLR VSGARKNRIV EVKTLNDRMV IVSIDPQATA STRPNIIPLN RPLMSVAQNC
     IDMTKKRPLS AEALYSRKVF IGGLPIDVAE EEVWATFGAF GKVLVDWPRR PEHNNGRGGD
     NMYEVEMGRR NLRSVSGYVF LVFTNERSVQ ELVNACEFYE NKYYLQLSSP TMSDKAVQVR
     PWRLSDIDYF CDDSCSVDHR RTVFIGGVPR PTRASDLASS LQDYYGKVSY VGIDIDPELK
     YPKGAARVTF ANSQSFVRAI SGRFVQVTHA ETNKRVEIKP YVMEDQHCDE CQGVLCKHNY
     APYFCGDSSC LQYYCEACWD RMHYIVCDSR ADHRPMVRTG DQTRILPRPP HHQSSHYSPR
     SHQMMNHDSM ESSNQSRGNT SSIISRIVNR NSAASVMDRQ TTKPFAATPA VIGY