CPB2_CAEJA
ID CPB2_CAEJA Reviewed; 594 AA.
AC Q6E3F0; Q6E3E8; Q6E3E9;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 25-MAY-2022, entry version 59.
DE RecName: Full=Cytoplasmic polyadenylation element-binding protein 2;
GN Name=cpb-2;
OS Caenorhabditis japonica.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=281687;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS A; B AND C).
RX PubMed=15231741; DOI=10.1101/gr.2639304;
RA Cho S., Jin S.W., Cohen A., Ellis R.E.;
RT "A phylogeny of Caenorhabditis reveals frequent loss of introns during
RT nematode evolution.";
RL Genome Res. 14:1207-1220(2004).
CC -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC binds to and regulates the translation of specific mRNAs.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=a;
CC IsoId=Q6E3F0-1; Sequence=Displayed;
CC Name=b;
CC IsoId=Q6E3F0-2; Sequence=VSP_011934;
CC Name=c;
CC IsoId=Q6E3F0-3; Sequence=VSP_011935;
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DR EMBL; AY589621; AAT72422.1; -; Genomic_DNA.
DR EMBL; AY589621; AAT72423.1; -; Genomic_DNA.
DR EMBL; AY589621; AAT72424.1; -; Genomic_DNA.
DR EMBL; AY589614; AAT72451.1; -; mRNA.
DR EMBL; AY589615; AAT72452.1; -; mRNA.
DR EMBL; AY589616; AAT72453.1; -; mRNA.
DR AlphaFoldDB; Q6E3F0; -.
DR SMR; Q6E3F0; -.
DR STRING; 281687.CJA09303; -.
DR PRIDE; Q6E3F0; -.
DR eggNOG; KOG0129; Eukaryota.
DR HOGENOM; CLU_034584_0_0_1; -.
DR InParanoid; Q6E3F0; -.
DR Proteomes; UP000005237; Unassembled WGS sequence.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:InterPro.
DR GO; GO:0045182; F:translation regulator activity; IEA:InterPro.
DR Gene3D; 3.30.70.330; -; 2.
DR Gene3D; 4.10.640.40; -; 1.
DR InterPro; IPR032296; CEBP_ZZ.
DR InterPro; IPR038446; CEBP_ZZ_sf.
DR InterPro; IPR034819; CPEB.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR12566; PTHR12566; 1.
DR Pfam; PF16366; CEBP_ZZ; 1.
DR Pfam; PF16367; RRM_7; 2.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF54928; SSF54928; 2.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome; RNA-binding.
FT CHAIN 1..594
FT /note="Cytoplasmic polyadenylation element-binding protein
FT 2"
FT /id="PRO_0000081514"
FT DOMAIN 458..540
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 72..91
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 367..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..195
FT /note="Missing (in isoform c)"
FT /evidence="ECO:0000303|PubMed:15231741"
FT /id="VSP_011935"
FT VAR_SEQ 1..51
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000303|PubMed:15231741"
FT /id="VSP_011934"
SQ SEQUENCE 594 AA; 68034 MW; 78AA09365D04275F CRC64;
MSKSRRVFLS MQDDDDFWGN GDRFEEEKSC LAAKAKQRSC PVVEMEEDDE EMEEKYFFKQ
SHLVRQRLEQ MKEREKVDEE KEGVERREEN GFSGKPWKFR VDSDEHEMKS DDVVTEDRSI
MGTKTFNSDF DDKSAIKSSL SMSLESNDVF YANYRNFFRG RPEVHFLIRC LFEKNPETFD
NQFIDLYEKT RKRLEMYPNP HINQILRRTL SSSNATETRV RSKHAVVVSN FREPDRRLGR
YSKYYYHHNV GPEVYSRKVF VGGLPACVTE DDILGFFSRY GRLQVDWPSK HYGGSKSDSD
PSLCSEIITP PAPLSHLSMA SPPFGQINPF MSGYVAPAET RGGFLRASGF SEGGGFGGGF
GGGIGGGGGF NSGSGSGNGT KSDGSTSEKR QSHLGYVFLL FEKERSVRDL VAECFEEEEG
LFITLESSLE PIRVQIRPWL LADAEFLMDF NVPINTKLVA FIGGVPRPLK AVELAHFFEQ
TYGNVVCVGI DIDNKFKYPR GSGRVAFSNY DAYVQAITDR YIVLDHEDIH KRVEIKPYFF
HNQSCEECSG RYHRQHAPFF CPSLECFQYY CEPCWHKMHA HPSRFHHMPV VKGV
