ID   CPB3_CAEBR              Reviewed;         753 AA.
AC   Q6E3D5; A8WW50;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Cytoplasmic polyadenylation element-binding protein 3;
GN   Name=cpb-3; ORFNames=CBG04067;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=15231741; DOI=10.1101/gr.2639304;
RA   Cho S., Jin S.W., Cohen A., Ellis R.E.;
RT   "A phylogeny of Caenorhabditis reveals frequent loss of introns during
RT   nematode evolution.";
RL   Genome Res. 14:1207-1220(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC       binds to and regulates the translation of specific mRNAs.
CC       {ECO:0000250}.
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DR   EMBL; AY589636; AAT72443.1; -; Genomic_DNA.
DR   EMBL; AY589606; AAT72414.1; -; mRNA.
DR   EMBL; HE600906; CAP24859.3; -; Genomic_DNA.
DR   RefSeq; XP_002639472.1; XM_002639426.1.
DR   AlphaFoldDB; Q6E3D5; -.
DR   SMR; Q6E3D5; -.
DR   STRING; 6238.CBG04067; -.
DR   EnsemblMetazoa; CBG04067.1; CBG04067.1; WBGene00026813.
DR   GeneID; 8581465; -.
DR   KEGG; cbr:CBG_04067; -.
DR   CTD; 8581465; -.
DR   WormBase; CBG04067; CBP06639; WBGene00026813; Cbr-cpb-3.
DR   eggNOG; KOG0129; Eukaryota.
DR   HOGENOM; CLU_377774_0_0_1; -.
DR   InParanoid; Q6E3D5; -.
DR   OMA; IEMGYLH; -.
DR   OrthoDB; 534330at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0008135; F:translation factor activity, RNA binding; IBA:GO_Central.
DR   GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 4.10.640.40; -; 1.
DR   InterPro; IPR032296; CEBP_ZZ.
DR   InterPro; IPR038446; CEBP_ZZ_sf.
DR   InterPro; IPR034819; CPEB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12566; PTHR12566; 1.
DR   Pfam; PF16366; CEBP_ZZ; 1.
DR   Pfam; PF16367; RRM_7; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..753
FT                   /note="Cytoplasmic polyadenylation element-binding protein
FT                   3"
FT                   /id="PRO_0000081516"
FT   DOMAIN          298..320
FT                   /note="RRM"
FT   REGION          111..286
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..589
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..186
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        220..253
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        263..278
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   753 AA;  83718 MW;  02C23B1DB078D385 CRC64;
     MNRNCASPEE GGTTEQLVKE ASDIVERDGF ENKKKPPTLK LEHVEVVGEK SPTPATVYDL
     FKKYKKPDIV TNSNGDDMNV GFDQLSSDEK NGFLRKLQML TVSSRKSVKV VGESTPSSAG
     RLLKKFAPSR KPTEKISVDE PPSRFNFFGR STKKLSDSDR PSSLPKKKSA RRLLFGKEEQ
     KPEPEVVKNR VLPAMTSQQS AKGAPIPINK PYRYQGPRGS LETPTDSPAK ISSNSSSSSP
     IPPVPTRNHF TSMNEESPSK KRTFSRQGLS NRDNLSNGSW HGELPPRDYT SPTFSRKIFV
     GGVPWDITEA ALKDSFGEFG SCAVEWPGQE ARYRSGQSNI APLTNLRNQS KYAGQAATGY
     VYMIFEDERA VASLLHECSQ EIGGAGEWYF KIRAQRSKST EIRQVQIIPW VTSDSMFCED
     ESLLETGIEP KRTVFVGALH GMMTAQVLHW IMEDCFGSVE CVQLDTDKFK YPIGSGRVTF
     REHGAYFKAI EMGYLHVHTS KFRKRVQIDP FLESTSCMVC TTESAQCFCR NRNCFKYYCH
     TCWAIDHGKD NADDVHVPVI VPSSASKAYA GPHRRPHLTS NSLSKSHGCS TNNQLSHVLS
     PGFPMIVGGP SQTLSALYGY IQNNQQMMLT PAVYETPMTP PSNESNAKRR SFTEFQNPAI
     FFNPSSMMTP QKSATCSETP VPAFFTNSAA FLTPNSNYYG SPNHSSSNIS QSPQQYYGAN
     LYYGYMPPQV AYDGSTNGSK LSPIHVPHIP NYQ