ID   CPB3_CAEEL              Reviewed;         745 AA.
AC   O01835;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Cytoplasmic polyadenylation element-binding protein 3;
GN   Name=cpb-3; ORFNames=B0414.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RX   PubMed=11040214; DOI=10.1101/gad.831700;
RA   Luitjens C., Gallegos M., Kraemer B., Kimble J., Wickens M.;
RT   "CPEB proteins control two key steps in spermatogenesis in C. elegans.";
RL   Genes Dev. 14:2596-2609(2000).
CC   -!- FUNCTION: Cytoplasmic polyadenylation element binding protein that
CC       binds to and regulates the translation of specific mRNAs (By
CC       similarity). May not be required for oogenesis. {ECO:0000250,
CC       ECO:0000269|PubMed:11040214}.
CC   -!- DEVELOPMENTAL STAGE: Expressed maternally in oocytes.
CC       {ECO:0000269|PubMed:11040214}.
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DR   EMBL; FO080197; CCD61905.1; -; Genomic_DNA.
DR   PIR; T15230; T15230.
DR   RefSeq; NP_491680.2; NM_059279.6.
DR   AlphaFoldDB; O01835; -.
DR   SMR; O01835; -.
DR   BioGRID; 37699; 4.
DR   STRING; 6239.B0414.5; -.
DR   iPTMnet; O01835; -.
DR   EPD; O01835; -.
DR   PaxDb; O01835; -.
DR   PeptideAtlas; O01835; -.
DR   EnsemblMetazoa; B0414.5.1; B0414.5.1; WBGene00000772.
DR   GeneID; 172244; -.
DR   KEGG; cel:CELE_B0414.5; -.
DR   UCSC; B0414.5; c. elegans.
DR   CTD; 172244; -.
DR   WormBase; B0414.5; CE41548; WBGene00000772; cpb-3.
DR   eggNOG; KOG0129; Eukaryota.
DR   GeneTree; ENSGT00940000155524; -.
DR   HOGENOM; CLU_377774_0_0_1; -.
DR   InParanoid; O01835; -.
DR   OMA; IEMGYLH; -.
DR   OrthoDB; 534330at2759; -.
DR   PRO; PR:O01835; -.
DR   Proteomes; UP000001940; Chromosome I.
DR   Bgee; WBGene00000772; Expressed in germ line (C elegans) and 3 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:1990124; C:messenger ribonucleoprotein complex; IBA:GO_Central.
DR   GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR   GO; GO:0000900; F:mRNA regulatory element binding translation repressor activity; IBA:GO_Central.
DR   GO; GO:0043022; F:ribosome binding; IBA:GO_Central.
DR   GO; GO:0008135; F:translation factor activity, RNA binding; IBA:GO_Central.
DR   GO; GO:2000766; P:negative regulation of cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 3.30.70.330; -; 2.
DR   Gene3D; 4.10.640.40; -; 1.
DR   InterPro; IPR032296; CEBP_ZZ.
DR   InterPro; IPR038446; CEBP_ZZ_sf.
DR   InterPro; IPR034819; CPEB.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR12566; PTHR12566; 1.
DR   Pfam; PF16366; CEBP_ZZ; 1.
DR   Pfam; PF16367; RRM_7; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome; RNA-binding.
FT   CHAIN           1..745
FT                   /note="Cytoplasmic polyadenylation element-binding protein
FT                   3"
FT                   /id="PRO_0000081517"
FT   DOMAIN          297..319
FT                   /note="RRM"
FT   REGION          1..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        123..143
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..174
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..252
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..275
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   745 AA;  83179 MW;  4D1F7BBC978669B4 CRC64;
     MNLNDRVEGI GNERSIVAKS TERKNKIPPS LKLSPVESVG EKSPTPATVY DLFKKYHKSD
     SVKPTEEDNM NVGFDKLSTD EKNGFLRKLQ MLTVGSKKSS KVDESTPSPA NRLLKKIVPS
     RRTSTEHPNS SNRMHIFGSS RTTKKSIDSE RNSQRKKSAR RLNFERDAEQ KKDSTKTNNS
     SFVAEMTREY EKIVISKGAP VPINKANRNL YRNPRGSLET PTDSPQKGFS SSTESSPSDS
     MNQFPSREHF TSANEESPMK RKNFQQEHGN KNRDSDATWF GELPPRDYTS PTFSRKIFVG
     GVPWDITEAA LKDSFGEFGS CAVEWPGQEA RYRSGQSNLA PSNGSLRAQT KYTGQAATGY
     VYMIFEDERA VASLLHECSQ EIGGAGEWYF KIRAQRSKST EIRQVQIIPW VTSDSMFCED
     DTLLETGIEP KRTVFVGALH GMMTAQVLHS IMEDCFGAVE CVQLDTDKFK YPIGSGRVTF
     REHGAYFKAI EMGYLHVYTS KFRKRVQIDP FLESTCCMVC NSQSAHCFCR NKNCFKYYCH
     NCWALDHGKD DDQEVHIPVI VPSSASKAFP GATTRRSQVS SSLSLKNGSN NSQVNNSIPH
     FPSAGFPIIV GAPAQTLSAL YGYIQNGQQL LKPAVFEPPM TPSPSEINKN RRSFTEFSTP
     PTVFFNSTPV ISPQKSVSDG SPLPAYYNSA AFLTPPPTYY GSPNHPTSSN ISQPQQPYYG
     ANLYYGFIPP QQHPSAMMRS PNYGQ