CPC1_NEUCR
ID CPC1_NEUCR Reviewed; 270 AA.
AC P11115; Q7RZG6;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 2.
DT 25-MAY-2022, entry version 142.
DE RecName: Full=Cross-pathway control protein 1;
GN Name=cpc-1; ORFNames=B2C22.100, NCU04050;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2967496; DOI=10.1073/pnas.85.11.3728;
RA Paluh J.L., Orbach M.J., Legerton T.L., Yanofsky C.;
RT "The cross-pathway control gene of Neurospora crassa, cpc-1, encodes a
RT protein similar to GCN4 of yeast and the DNA-binding domain of the oncogene
RT v-jun-encoded protein.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:3728-3732(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
RN [4]
RP DNA-BINDING, AND DIMERIZATION.
RX PubMed=1824960; DOI=10.1128/mcb.11.2.935-944.1991;
RA Paluh J.L., Yanofsky C.;
RT "Characterization of Neurospora CPC1, a bZIP DNA-binding protein that does
RT not require aligned heptad leucines for dimerization.";
RL Mol. Cell. Biol. 11:935-944(1991).
CC -!- FUNCTION: In N.crassa grown under amino acid starvation conditions,
CC this protein is required for increasing the transcription of the genes
CC coding for many amino acid biosynthetic pathways enzymes. This
CC transcription factor binds and recognize the DNA sequence: 5'-TGACTC-
CC 3'.
CC -!- SUBUNIT: Binds DNA as a dimer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the bZIP family. GCN4 subfamily. {ECO:0000305}.
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DR EMBL; J03262; AAA33577.1; -; Genomic_DNA.
DR EMBL; BX897679; CAE85619.1; -; Genomic_DNA.
DR EMBL; CM002241; EAA28429.1; -; Genomic_DNA.
DR PIR; A30208; A30208.
DR RefSeq; XP_957665.1; XM_952572.3.
DR AlphaFoldDB; P11115; -.
DR SMR; P11115; -.
DR STRING; 5141.EFNCRP00000003676; -.
DR EnsemblFungi; EAA28429; EAA28429; NCU04050.
DR GeneID; 3873836; -.
DR KEGG; ncr:NCU04050; -.
DR VEuPathDB; FungiDB:NCU04050; -.
DR HOGENOM; CLU_029566_0_0_1; -.
DR InParanoid; P11115; -.
DR OMA; YWKALAQ; -.
DR Proteomes; UP000001805; Chromosome 5, Linkage Group VI.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0001080; P:nitrogen catabolite activation of transcription from RNA polymerase II promoter; IBA:GO_Central.
DR GO; GO:1903833; P:positive regulation of cellular response to amino acid starvation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 1: Evidence at protein level;
KW Activator; Amino-acid biosynthesis; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..270
FT /note="Cross-pathway control protein 1"
FT /id="PRO_0000076488"
FT DOMAIN 216..270
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 114..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 153..213
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 222..240
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 241..248
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT COMPBIAS 177..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 29226 MW; 4589AC5EAE05C2FA CRC64;
MFSELDLLDF ATFDGGATTE AAFASPANQT YDLSSSVPSS VSNMGTVSPQ ELLLHEPYLS
APSSTALTAL TSPSLFDGSP DFDTFDISPN FGHSDLENPD TWFSLFPDAT PLPQAQAQVQ
TQPQTQTQTE QQTQPLPELV QSVQPTVQPT VEQTVHSVEA SPATPSEDLE VLSPGSGHQR
RKSSVSPPSG RHSSVAGVGS RRRDKPLPPI IVEDPSDVVA MKRARNTLAA RKSRERKAQR
LEELEAKIEE LIAERDRWKN LALAHGASTE
