ID   CPDP_YERPE              Reviewed;         343 AA.
AC   Q8ZD92; Q0WDJ4; Q8CLI4;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   25-MAY-2022, entry version 116.
DE   RecName: Full=Probable 3',5'-cyclic-nucleotide phosphodiesterase;
DE            Short=3':5'-CNP;
DE            Short=PDEase;
DE            EC=3.1.4.17;
DE   Flags: Precursor;
GN   Name=cpdP; OrderedLocusNames=YPO2696, y1271, YP_2500;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-
CC         phosphate + H(+); Xref=Rhea:RHEA:14653, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57867, ChEBI:CHEBI:58464; EC=3.1.4.17;
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase class-II
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM84845.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=AAS62699.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AL590842; CAL21315.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM84845.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS62699.1; ALT_INIT; Genomic_DNA.
DR   PIR; AH0328; AH0328.
DR   RefSeq; YP_002347644.1; NC_003143.1.
DR   AlphaFoldDB; Q8ZD92; -.
DR   SMR; Q8ZD92; -.
DR   STRING; 214092.YPO2696; -.
DR   PaxDb; Q8ZD92; -.
DR   DNASU; 1146218; -.
DR   EnsemblBacteria; AAM84845; AAM84845; y1271.
DR   EnsemblBacteria; AAS62699; AAS62699; YP_2500.
DR   KEGG; ype:YPO2696; -.
DR   KEGG; ypk:y1271; -.
DR   KEGG; ypm:YP_2500; -.
DR   PATRIC; fig|214092.21.peg.3134; -.
DR   eggNOG; COG5212; Bacteria.
DR   HOGENOM; CLU_016658_2_0_6; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity; IBA:GO_Central.
DR   GO; GO:0047555; F:3',5'-cyclic-GMP phosphodiesterase activity; IBA:GO_Central.
DR   GO; GO:0006198; P:cAMP catabolic process; IBA:GO_Central.
DR   GO; GO:0046069; P:cGMP catabolic process; IBA:GO_Central.
DR   GO; GO:1902660; P:negative regulation of glucose mediated signaling pathway; IBA:GO_Central.
DR   CDD; cd07735; class_II_PDE_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; -; 1.
DR   InterPro; IPR024225; cAMP-PdiesteraseII_CS.
DR   InterPro; IPR000396; Pdiesterase2.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   PANTHER; PTHR28283; PTHR28283; 2.
DR   Pfam; PF02112; PDEase_II; 1.
DR   PIRSF; PIRSF000962; Cyc_nuc_PDEase; 1.
DR   PRINTS; PR00388; PDIESTERASE2.
DR   SUPFAM; SSF56281; SSF56281; 1.
DR   PROSITE; PS00607; PDEASE_II; 1.
PE   3: Inferred from homology;
KW   cAMP; Hydrolase; Periplasm; Reference proteome; Signal.
FT   SIGNAL          1..36
FT                   /evidence="ECO:0000255"
FT   CHAIN           37..343
FT                   /note="Probable 3',5'-cyclic-nucleotide phosphodiesterase"
FT                   /id="PRO_0000023355"
SQ   SEQUENCE   343 AA;  37874 MW;  B694C1AEA9C01F57 CRC64;
     MKYLSIKSAS DKIKSGLLKT GVILSFSLFS SLSTAAFEVV ALGVDGGVSD GNLTSYLIRN
     DSQPLYLGLD AGSVLPGIAR ALEKGHFAAI TDAMAAPLTR QGYIFRQSIN SYFISHAHLD
     HVSGLIIGSP DDSKKTIYAS ADTIDVLRNY YFNWRVWPNF TDSGSGARLG TYRMQVVRPA
     QSLSLGLTRL TGEMYPLSHD KSPSSMLLIS SNNEFFAYFG DTGPDDVEKS KNLDTVWRKL
     AEKVTQQQLK GMIIEVSYPN DVADNKLFGH MTPTWLLKEL KKLEQYSGEG QPLKGLPVVI
     SHIKPSFQQG QDVRKLILSE LQQGNDMGIE FILMEQGDSQ KFQ