CPED1_HUMAN
ID CPED1_HUMAN Reviewed; 1026 AA.
AC A4D0V7; A8K1R3; Q6UXT1; Q86T76; Q86T84; Q8N2T5; Q96NC9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2007, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Cadherin-like and PC-esterase domain-containing protein 1;
DE Flags: Precursor;
GN Name=CPED1; Synonyms=C7orf58; ORFNames=UNQ9432/PRO34713;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT GLY-551.
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS GLY-551
RP AND GLY-708.
RC TISSUE=Hippocampus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLY-708.
RC TISSUE=Spinal cord;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 181-802 (ISOFORM 2), AND VARIANT
RP GLY-551.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=A4D0V7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=A4D0V7-2; Sequence=VSP_031140, VSP_031141;
CC -!- SIMILARITY: Belongs to the PC-esterase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30538.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY358220; AAQ88587.1; -; mRNA.
DR EMBL; AK055624; BAB70974.1; -; mRNA.
DR EMBL; AK289978; BAF82667.1; -; mRNA.
DR EMBL; AL832619; CAD89961.1; -; mRNA.
DR EMBL; AL832638; CAD89953.1; -; mRNA.
DR EMBL; CH236947; EAL24348.1; -; Genomic_DNA.
DR EMBL; BC030538; AAH30538.1; ALT_INIT; mRNA.
DR CCDS; CCDS34739.1; -. [A4D0V7-1]
DR CCDS; CCDS47690.1; -. [A4D0V7-2]
DR RefSeq; NP_001099003.1; NM_001105533.1. [A4D0V7-2]
DR RefSeq; NP_079189.4; NM_024913.4. [A4D0V7-1]
DR AlphaFoldDB; A4D0V7; -.
DR BioGRID; 123041; 1.
DR IntAct; A4D0V7; 1.
DR STRING; 9606.ENSP00000309772; -.
DR GlyGen; A4D0V7; 6 sites.
DR iPTMnet; A4D0V7; -.
DR PhosphoSitePlus; A4D0V7; -.
DR BioMuta; CPED1; -.
DR jPOST; A4D0V7; -.
DR MassIVE; A4D0V7; -.
DR MaxQB; A4D0V7; -.
DR PaxDb; A4D0V7; -.
DR PeptideAtlas; A4D0V7; -.
DR PRIDE; A4D0V7; -.
DR ProteomicsDB; 598; -. [A4D0V7-1]
DR ProteomicsDB; 599; -. [A4D0V7-2]
DR Antibodypedia; 2305; 52 antibodies from 15 providers.
DR DNASU; 79974; -.
DR Ensembl; ENST00000310396.10; ENSP00000309772.5; ENSG00000106034.18. [A4D0V7-1]
DR Ensembl; ENST00000450913.6; ENSP00000406122.2; ENSG00000106034.18. [A4D0V7-2]
DR GeneID; 79974; -.
DR KEGG; hsa:79974; -.
DR MANE-Select; ENST00000310396.10; ENSP00000309772.5; NM_024913.5; NP_079189.4.
DR UCSC; uc003vjq.5; human. [A4D0V7-1]
DR CTD; 79974; -.
DR DisGeNET; 79974; -.
DR GeneCards; CPED1; -.
DR HGNC; HGNC:26159; CPED1.
DR HPA; ENSG00000106034; Tissue enhanced (ovary).
DR neXtProt; NX_A4D0V7; -.
DR OpenTargets; ENSG00000106034; -.
DR PharmGKB; PA162380636; -.
DR VEuPathDB; HostDB:ENSG00000106034; -.
DR eggNOG; ENOG502QQAY; Eukaryota.
DR GeneTree; ENSGT00390000015216; -.
DR HOGENOM; CLU_011328_0_0_1; -.
DR InParanoid; A4D0V7; -.
DR OMA; VHGTKLY; -.
DR OrthoDB; 469326at2759; -.
DR PhylomeDB; A4D0V7; -.
DR TreeFam; TF332741; -.
DR PathwayCommons; A4D0V7; -.
DR SignaLink; A4D0V7; -.
DR BioGRID-ORCS; 79974; 14 hits in 1076 CRISPR screens.
DR ChiTaRS; CPED1; human.
DR GeneWiki; FLJ21986; -.
DR GenomeRNAi; 79974; -.
DR Pharos; A4D0V7; Tdark.
DR PRO; PR:A4D0V7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A4D0V7; protein.
DR Bgee; ENSG00000106034; Expressed in cauda epididymis and 174 other tissues.
DR ExpressionAtlas; A4D0V7; baseline and differential.
DR Genevisible; A4D0V7; HS.
DR GO; GO:0005783; C:endoplasmic reticulum; IDA:LIFEdb.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Reference proteome; Signal.
FT SIGNAL 1..34
FT /evidence="ECO:0000255"
FT CHAIN 35..1026
FT /note="Cadherin-like and PC-esterase domain-containing
FT protein 1"
FT /id="PRO_0000317732"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 404
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 413
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 737
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 791
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 985
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 771..783
FT /note="ILFIGDSTNRGIM -> LGVDVQRVPRSRN (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031140"
FT VAR_SEQ 784..1026
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_031141"
FT VARIANT 326
FT /note="I -> T (in dbSNP:rs17143165)"
FT /id="VAR_038664"
FT VARIANT 551
FT /note="A -> G (in dbSNP:rs41281692)"
FT /evidence="ECO:0000269|PubMed:12975309,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334"
FT /id="VAR_038665"
FT VARIANT 708
FT /note="E -> G (in dbSNP:rs35793694)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_038666"
FT VARIANT 949
FT /note="K -> T (in dbSNP:rs798911)"
FT /id="VAR_038667"
FT CONFLICT 173
FT /note="C -> R (in Ref. 3; CAD89961)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="E -> G (in Ref. 2; BAF82667)"
FT /evidence="ECO:0000305"
FT CONFLICT 262
FT /note="I -> T (in Ref. 3; CAD89961)"
FT /evidence="ECO:0000305"
FT CONFLICT 641
FT /note="K -> R (in Ref. 3; CAD89961)"
FT /evidence="ECO:0000305"
FT CONFLICT 795
FT /note="Q -> R (in Ref. 3; CAD89961)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1026 AA; 117491 MW; 7C3E91FAF7494440 CRC64;
MVCRPVFPCR RRFCPRPFLV GLVVAICLFY QTLTLRGSRK LTAAAPGAVP HTSTETQASR
CKKGFSQDKQ CFLLSGNAQE TRKVKESMET HFGSHGRRAI LYRPPFYSKT ELQLHQHILT
QHGYTVVIAE ERLNAGLGPG LLEQGDLGSW DLLICLSSKK AEGTPCISKE VMCQLGLHQK
ANRLPEIQQP LCRKEGLCQI VRRFPELQLP VSPSVCLDQG MQLKPSTSSH LLKTVKPRVW
KPGDWSREQL NETTVLAPHE TIFRAEDLSV ILKAYVLVTS LTPLRAFIHS TGTVWNPPKK
KRFTVKLQTF FETFLRASSP QQAFDIMKEA IGKLLLAAEV FSETSTLGPK TFHRCRFCFQ
LLTFDIGYGS FMYPVVLQVH EHLNFQDYDN MDFEDQNTEE FLLNDTFNFL FPNESSLSIF
SEIFQRLYRS DVFKGENYQK ELNQCLSLEE INSIMTFIKE LGSLGQFQLL FPSTTPGIQS
LMHEFYDVAN PVGNPGSVLT QYWSLLNVFE QFQFMNKKTQ PHPLEWNSFT EDKNIEKPQV
PFDAIENKKA AVPQIKNENK EIHCSDDENT PCHIKQIFTH PHLELNPDFH PKIKDYYCEV
PFDVVTVTIG VETPKCLCKV HLYEQAGPSF ASYPLGLGMN KISIFVVDES PAHGETLITY
KLTIYREDRP SLPLFEAFTA CGFVQDCGLL IHPEETCGLQ PISSDYIEAI LQSELKRCPS
GDMKGQWIVP CLSCSDNRTC DWREITWQPH NCQYGVLTKP QLQQCLGGRK ILFIGDSTNR
GIMYYLIERL NETLQEWQKV HGTKFYHNVN GGKTLISYSY YPQFWISPSL RPTFENALEH
LLQRSRPLEN TGQTVLVVGG VQWLNSNHLQ IIHKVLKREN LLNILVIIKT LGIGFHLPVD
GVHFLTQSEV QNLWKENLII LDTAKKHGYE VVDTFTITMG RYKEFLQGKC GCHFHEVVKS
KLSKEYNFIK MKRSRNHIMG RYFSNQSKLQ QGTVTNFRSP YHVRGPINQV CSEILLSRMC
ANKRTM
