ID   CPFB3_XENBO             Reviewed;          22 AA.
AC   C0HK90;
DT   30-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2016, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Caerulein precursor fragment B3 {ECO:0000303|PubMed:20656059};
DE            Short=CPF-B3 {ECO:0000303|PubMed:20656059};
OS   Xenopus borealis (Kenyan clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8354 {ECO:0000303|PubMed:20656059};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000303|PubMed:20656059};
RX   PubMed=20656059; DOI=10.1016/j.cbpc.2010.07.007;
RA   Mechkarska M., Ahmed E., Coquet L., Leprince J., Jouenne T., Vaudry H.,
RA   King J.D., Conlon J.M.;
RT   "Antimicrobial peptides with therapeutic potential from skin secretions of
RT   the Marsabit clawed frog Xenopus borealis (Pipidae).";
RL   Comp. Biochem. Physiol. 152:467-472(2010).
CC   -!- FUNCTION: Has antibacterial and antifungal activity.
CC       {ECO:0000250|UniProtKB:C0HK89}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20656059}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:20656059}.
CC   -!- MASS SPECTROMETRY: Mass=2356.2; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20656059};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000303|PubMed:20656059}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; C0HK90; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Antibiotic; Antimicrobial; Direct protein sequencing; Fungicide; Secreted.
FT   PEPTIDE         1..22
FT                   /note="Caerulein precursor fragment B3"
FT                   /evidence="ECO:0000269|PubMed:20656059"
FT                   /id="PRO_0000438431"
SQ   SEQUENCE   22 AA;  2357 MW;  F7C9E8F665AE81FB CRC64;
     GLGSLLGSLF KFIPKLLPSI QQ