ID   CPFR4_XENRU             Reviewed;          27 AA.
AC   C0HKM8;
DT   05-JUL-2017, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2017, sequence version 1.
DT   25-MAY-2022, entry version 4.
DE   RecName: Full=Caerulein precursor fragment R4 {ECO:0000303|PubMed:27290612};
DE   AltName: Full=CPF-R4 {ECO:0000303|PubMed:27290612};
OS   Xenopus ruwenzoriensis (Uganda clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=105430 {ECO:0000303|PubMed:27290612};
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, AND MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000303|PubMed:27290612};
RX   PubMed=27290612; DOI=10.1016/j.cbd.2016.04.006;
RA   Coquet L., Kolodziejek J., Jouenne T., Nowotny N., King J.D., Conlon J.M.;
RT   "Peptidomic analysis of the extensive array of host-defense peptides in
RT   skin secretions of the dodecaploid frog Xenopus ruwenzoriensis (Pipidae).";
RL   Comp. Biochem. Physiol. 19:18-24(2016).
CC   -!- FUNCTION: Antimicrobial peptide. {ECO:0000250|UniProtKB:C0HK89}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27290612}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:27290612}.
CC   -!- MASS SPECTROMETRY: Mass=2601.5; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:27290612};
CC   -!- SIMILARITY: Belongs to the gastrin/cholecystokinin family.
CC       {ECO:0000305}.
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DR   AlphaFoldDB; C0HKM8; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antimicrobial; Direct protein sequencing;
KW   Secreted.
FT   PEPTIDE         1..27
FT                   /note="Caerulein precursor fragment R4"
FT                   /evidence="ECO:0000269|PubMed:27290612"
FT                   /id="PRO_0000440914"
SQ   SEQUENCE   27 AA;  2602 MW;  D25088DB93321356 CRC64;
     GFGSFLGKAL KAALKIGANA LGGSPQQ