CPH1_CANAL
ID CPH1_CANAL Reviewed; 656 AA.
AC P43079; A0A1D8PE14; Q59WD6; Q59WZ4;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 19-OCT-2011, sequence version 3.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Transcription factor CPH1;
GN Name=CPH1; Synonyms=ACPR; OrderedLocusNames=CAALFM_C107370CA;
GN ORFNames=CaO19.11912, CaO19.4433;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=8083193; DOI=10.1016/s0021-9258(17)31601-0;
RA Malathi K., Ganesan K., Datta A.;
RT "Identification of a putative transcription factor in Candida albicans that
RT can complement the mating defect of Saccharomyces cerevisiae ste12
RT mutants.";
RL J. Biol. Chem. 269:22945-22951(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1006;
RX PubMed=7992058; DOI=10.1126/science.7992058;
RA Liu H., Koehler J., Fink G.R.;
RT "Suppression of hyphal formation in Candida albicans by mutation of a STE12
RT homolog.";
RL Science 266:1723-1726(1994).
RN [3]
RP ERRATUM OF PUBMED:7992058.
RA Liu H., Koehler J., Fink G.R.;
RL Science 267:17-17(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [7]
RP CHARACTERIZATION.
RX PubMed=7802635; DOI=10.1006/bbrc.1994.2776;
RA Singh P., Ganesan K., Malathi K., Ghosh D., Datta A.;
RT "ACPR, a STE12 homologue from Candida albicans, is a strong inducer of
RT pseudohyphae in Saccharomyces cerevisiae haploids and diploids.";
RL Biochem. Biophys. Res. Commun. 205:1079-1085(1994).
CC -!- FUNCTION: Transcription factor involved in the formation of
CC pseudohyphae and hyphae. It is likely to play a role in the
CC developmental switch between yeast and mycelial forms. May be involved
CC in a signal transduction system, strengthening the possibility of a
CC sexual phase up to now undetected, and similar to that of the yeast
CC mating pathway.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the STE12 transcription factor family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA59355.1; Type=Erroneous termination; Note=Extended C-terminus.; Evidence={ECO:0000305};
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DR EMBL; L16451; AAA59355.1; ALT_TERM; Genomic_DNA.
DR EMBL; U15152; AAA64692.1; -; Genomic_DNA.
DR EMBL; CP017623; AOW26385.1; -; Genomic_DNA.
DR PIR; A54767; A54767.
DR RefSeq; XP_713877.1; XM_708784.2.
DR AlphaFoldDB; P43079; -.
DR BioGRID; 1227359; 3.
DR STRING; 237561.P43079; -.
DR PRIDE; P43079; -.
DR GeneID; 3644468; -.
DR KEGG; cal:CAALFM_C107370CA; -.
DR CGD; CAL0000198463; CPH1.
DR VEuPathDB; FungiDB:C1_07370C_A; -.
DR eggNOG; ENOG502QTVR; Eukaryota.
DR HOGENOM; CLU_019798_1_0_1; -.
DR InParanoid; P43079; -.
DR OrthoDB; 1248892at2759; -.
DR PHI-base; PHI:3504; -.
DR PHI-base; PHI:6802; -.
DR PHI-base; PHI:6804; -.
DR PHI-base; PHI:86; -.
DR PRO; PR:P43079; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:1990526; C:Ste12p-Dig1p-Dig2p complex; IBA:GO_Central.
DR GO; GO:1990527; C:Tec1p-Ste12p-Dig1p complex; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IDA:CGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IGI:CGD.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0044114; P:development of symbiont in host; IMP:CGD.
DR GO; GO:0042783; P:evasion of host immune response; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IMP:CGD.
DR GO; GO:0006012; P:galactose metabolic process; IMP:CGD.
DR GO; GO:1990277; P:parasexual reproduction with cellular fusion; IMP:CGD.
DR GO; GO:1900430; P:positive regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:1900445; P:positive regulation of filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:1900436; P:positive regulation of filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0007124; P:pseudohyphal growth; IMP:CGD.
DR GO; GO:1900428; P:regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:2000220; P:regulation of pseudohyphal growth; IBA:GO_Central.
DR GO; GO:1900231; P:regulation of single-species biofilm formation on inanimate substrate; IMP:CGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:CGD.
DR GO; GO:0019953; P:sexual reproduction; IBA:GO_Central.
DR InterPro; IPR003120; Ste12.
DR Pfam; PF02200; STE; 1.
DR SMART; SM00424; STE; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..656
FT /note="Transcription factor CPH1"
FT /id="PRO_0000079287"
FT DNA_BIND 44..154
FT /evidence="ECO:0000250"
FT REGION 205..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 575..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 575..618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 625..642
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 482
FT /note="I -> M (in strain: 1006)"
FT CONFLICT 610
FT /note="N -> K (in Ref. 1; AAA59355)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 656 AA; 72916 MW; DFCAEB7AF84BD281 CRC64;
MSITKTYNGD PTSLVPTQSV KESLRLIEDL KFFLATAPAN WQENQVIRRY YLNHDEGFVS
CVYWNNLYFI TGTDIVRCIV YKFEHFGRKI IDRKKFEEGI FSDLRNLKCG ADAILEPPRS
EFLEFLFKNS CLRTQKKQKV FFWFNVPHDK LMADALERDL KKEKMGQRPT TMAHREPALS
FHYDESSSLY TQLGKHMETQ KRINDAATSS TSNTATTLTD TGVSSGLNNT TSGGGSDSAT
STHNNNEAST KPSNGSEKSS PEYTTTARGR DEFGFLNEAT PSQYKANSDY EDDFPLDYIN
QTTQNSEDYI TLDANYQAGS YANMIEDNYD SFLDATLFIP PSLGVPTGTA ATATTSNQVA
FNDEYLIEQA QPIRTPLPPI SSSTISGLLQ PKSAAKFFSL QSANGGEEFF PAYQNDPSTA
NAGFVPPISA KYATQFATRQ VATPTYIKAI PQTGAAAATG NGGQPQQYYD QATGNAFYPA
EIPVSYNVVH PESEYWTNNS GAVATTAAAT APMYDASGFP IPINQSYMVM NEHEMVPYQY
MNSNGAMIGM IPPHQQQQQQ QQQIAMGYQS MLRQQQQQQQ QQQQQQPSST MTKKKKQIHS
FNNNKSLSSN GGGITKKSHD NNNHSKVKTS YGSLNDVVNS KVTKVINKEE VKQSQT
