ID   CPHL2_HUMAN             Reviewed;         400 AA.
AC   A0A1W2PPK0;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2017, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Cytoplasmic polyadenylated homeobox-like protein 2 {ECO:0000305};
GN   Name=CPHXL2 {ECO:0000312|HGNC:HGNC:55919};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15616553; DOI=10.1038/nature03187;
RA   Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA   Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA   Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA   Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA   Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA   Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA   Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA   Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA   Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA   Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA   Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA   Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA   Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA   Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA   Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA   Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA   Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA   Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA   Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA   DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA   Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA   Myers R.M., Rubin E.M., Pennacchio L.A.;
RT   "The sequence and analysis of duplication-rich human chromosome 16.";
RL   Nature 432:988-994(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
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DR   EMBL; AC025287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A1W2PPK0; -.
DR   SMR; A0A1W2PPK0; -.
DR   BioMuta; ENSG00000284484; -.
DR   MANE-Select; ENST00000640173.1; ENSP00000491197.1; NM_001395862.1; NP_001382791.1.
DR   GeneCards; ENSG00000284484; -.
DR   HGNC; HGNC:55919; CPHXL2.
DR   VEuPathDB; HostDB:ENSG00000284484; -.
DR   GeneTree; ENSGT00520000058758; -.
DR   OMA; CSFAKYC; -.
DR   Proteomes; UP000005640; Chromosome 16.
DR   RNAct; A0A1W2PPK0; protein.
DR   Bgee; ENSG00000284484; Expressed in calcaneal tendon and 17 other tissues.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001356; Homeobox_dom.
DR   Pfam; PF00046; Homeodomain; 1.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..400
FT                   /note="Cytoplasmic polyadenylated homeobox-like protein 2"
FT                   /id="PRO_0000454732"
FT   DNA_BIND        24..83
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   400 AA;  45221 MW;  34191CFDD54FBFCA CRC64;
     MSSQAFPAEE DHHNEERQTK KKRKTKHRHK FSEELLQELK EIFGENGYPD FTTRKTLANK
     FDCPVNVINN WFQNNRARLP PEERQRIFLT WKKHDFPVQA CPFLSLQETQ AAASNYATEQ
     SFSCAKRALM RRPGCSLLEK QRIACQQMGY NCFSLENQET PSQQVGSMCS SLEKQGIPSQ
     QVGSQCSYLV AGTEKHPGYA LEYGGDTGSE HSTAYRFLSY NSAECLHPPP SSVPYFHGER
     TETRESQHAS PFLLDYAQGA YGVKKDHCLC SFCLSLLQEQ QQNDWQYHPQ QHQQPQNYSE
     GMMLQEQLPM DSGPWDLEKQ WPSAQSQLQS QLPQNNGKPL CSQLQHVPPQ IAANSPLLPL
     GQDMQVGASS NSGLKCSSFR LRGLHGPATG TQGCSFAKYC