CPHXL_HUMAN
ID CPHXL_HUMAN Reviewed; 405 AA.
AC A0A1W2PPM1;
DT 05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2017, sequence version 1.
DT 03-AUG-2022, entry version 27.
DE RecName: Full=Cytoplasmic polyadenylated homeobox-like protein {ECO:0000305};
DE AltName: Full=Cytoplasmic polyadenylated homeobox 1;
GN Name=CPHXL {ECO:0000312|HGNC:HGNC:51815}; Synonyms=CPHX1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15616553; DOI=10.1038/nature03187;
RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G.,
RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E.,
RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M.,
RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C.,
RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M.,
RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M.,
RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D.,
RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L.,
RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E.,
RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H.,
RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y.,
RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J.,
RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D.,
RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S.,
RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A.,
RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M.,
RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H.,
RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A.,
RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J.,
RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J.,
RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M.,
RA Myers R.M., Rubin E.M., Pennacchio L.A.;
RT "The sequence and analysis of duplication-rich human chromosome 16.";
RL Nature 432:988-994(2004).
RN [2]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=27412763; DOI=10.1038/srep28995;
RA Madissoon E., Jouhilahti E.M., Vesterlund L., Toehoenen V., Krjutskov K.,
RA Petropoulos S., Einarsdottir E., Linnarsson S., Lanner F., Maansson R.,
RA Hovatta O., Buerglin T.R., Katayama S., Kere J.;
RT "Characterization and target genes of nine human PRD-like homeobox domain
RT genes expressed exclusively in early embryos.";
RL Sci. Rep. 6:28995-28995(2016).
CC -!- FUNCTION: Transcription factor that acts as activator.
CC {ECO:0000269|PubMed:27412763}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC -!- DEVELOPMENTAL STAGE: Expressed in single blastomeres from 8-cell stage
CC embryos. {ECO:0000269|PubMed:27412763}.
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DR EMBL; AC009122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025287; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS86543.1; -.
DR AlphaFoldDB; A0A1W2PPM1; -.
DR SMR; A0A1W2PPM1; -.
DR BioMuta; ENSG00000283755; -.
DR MassIVE; A0A1W2PPM1; -.
DR Ensembl; ENST00000640559.2; ENSP00000491599.1; ENSG00000283755.2.
DR MANE-Select; ENST00000640559.2; ENSP00000491599.1; NM_001355613.1; NP_001342542.1.
DR GeneCards; CPHXL; -.
DR HGNC; HGNC:51815; CPHXL.
DR HPA; ENSG00000283755; Not detected.
DR MIM; 618700; gene.
DR neXtProt; NX_A0A1W2PPM1; -.
DR VEuPathDB; HostDB:ENSG00000283755; -.
DR GeneTree; ENSGT00520000058758; -.
DR OMA; IFGENCY; -.
DR PRO; PR:A0A1W2PPM1; -.
DR Proteomes; UP000005640; Chromosome 16.
DR RNAct; A0A1W2PPM1; protein.
DR Bgee; ENSG00000283755; Expressed in calcaneal tendon and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001356; Homeobox_dom.
DR Pfam; PF00046; Homeodomain; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..405
FT /note="Cytoplasmic polyadenylated homeobox-like protein"
FT /id="PRO_0000447307"
FT DNA_BIND 28..87
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 405 AA; 45714 MW; D0786215762FBC17 CRC64;
MNLDGTSGGF PAEEDHHNEE RQTKNKRKTK HRHKFSEELL QELKEIFGEN CYPDYTTRKT
LAIKFDCPVN VIDNWFQNKR ARLPPAERRR IFVLQKKHDF PVQAHSFLSC QETQAAAHNY
ATKQSLSGAQ RALMRRAGCS HLEKQWIPSQ EMGYNCFSLE NQETPSQQVG PQCSYLEKPG
IPSQQVGSQC SYLEKLGIPS QQVASQSSYL VTGTEKHPGC AMGYGGDTGS GHSGSGHSTA
YHFLSYNSAE CLHPPPSSVP YFHGERTETK ESQHASPFLL DYAQGAYGVK KDHCLCSFCL
SLLGQQQQND WQYHLQQHQQ PQNYLEGMML QEQLPMDSGP WDLGKQWSSA QSQLQSQLPQ
NNGKPLCSQL QHMSLQIAAD SPLLPLGQDM QERASEQPRT QMQQL
