ID   CPI1_PIG                Reviewed;         103 AA.
AC   P35479;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Leukocyte cysteine proteinase inhibitor 1;
DE   AltName: Full=PLCPI;
DE   AltName: Full=Stefin-D1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Leukocyte;
RX   PubMed=8262248; DOI=10.1016/0014-5793(93)80822-c;
RA   Lenarcic B., Ritonja A., Dolenc I., Stoka V., Berbic S., Pungercar J.,
RA   Strukelj B., Turk V.;
RT   "Pig leukocyte cysteine proteinase inhibitor (PLCPI), a new member of the
RT   stefin family.";
RL   FEBS Lett. 336:289-292(1993).
RN   [2]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Thymus;
RX   PubMed=8898076; DOI=10.1016/0014-5793(96)00984-2;
RA   Lenarcic B., Krizaj I., Zunec P., Turk V.;
RT   "Differences in specificity for the interactions of stefins A, B and D with
RT   cysteine proteinases.";
RL   FEBS Lett. 395:113-118(1996).
CC   -!- FUNCTION: Potent inhibitor of cathepsins L and S, and papain.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR   PIR; S40455; S40455.
DR   AlphaFoldDB; P35479; -.
DR   SMR; P35479; -.
DR   MEROPS; I25.001; -.
DR   PeptideAtlas; P35479; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR   CDD; cd00042; CY; 1.
DR   InterPro; IPR000010; Cystatin_dom.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR018073; Prot_inh_cystat_CS.
DR   InterPro; IPR001713; Prot_inh_stefin.
DR   PANTHER; PTHR11414; PTHR11414; 1.
DR   Pfam; PF00031; Cystatin; 1.
DR   PRINTS; PR00295; STEFINA.
DR   SMART; SM00043; CY; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
DR   PROSITE; PS00287; CYSTATIN; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW   Reference proteome; Thiol protease inhibitor.
FT   CHAIN           1..103
FT                   /note="Leukocyte cysteine proteinase inhibitor 1"
FT                   /id="PRO_0000207133"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           51..55
FT                   /note="Secondary area of contact"
FT   SITE            9
FT                   /note="Reactive site"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         1
FT                   /note="Blocked amino end (Met); partial"
SQ   SEQUENCE   103 AA;  11767 MW;  A28B0533D274A55D CRC64;
     MESEEMLAGG LTEPRPATPE IQEIANKVKP QLEEKTNKTY EKFEAIIYRS QVVAGTNYYI
     KVHVGGNNYV HIRVFQSLPH QEDPLKLIGY QVDKTKDDEL TGF