CPI2_PIG
ID CPI2_PIG Reviewed; 35 AA.
AC P80736;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Leukocyte cysteine proteinase inhibitor 2;
DE AltName: Full=PLCPII;
DE AltName: Full=Stefin-D2;
DE Flags: Fragment;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Thymus;
RX PubMed=8898076; DOI=10.1016/0014-5793(96)00984-2;
RA Lenarcic B., Krizaj I., Zunec P., Turk V.;
RT "Differences in specificity for the interactions of stefins A, B and D with
RT cysteine proteinases.";
RL FEBS Lett. 395:113-118(1996).
CC -!- FUNCTION: Potent inhibitor of cathepsins L and S, and papain.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the cystatin family. {ECO:0000305}.
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DR AlphaFoldDB; P80736; -.
DR SMR; P80736; -.
DR PeptideAtlas; P80736; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR InterPro; IPR000010; Cystatin_dom.
DR InterPro; IPR046350; Cystatin_sf.
DR InterPro; IPR001713; Prot_inh_stefin.
DR Pfam; PF00031; Cystatin; 1.
DR PRINTS; PR00295; STEFINA.
DR SUPFAM; SSF54403; SSF54403; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Protease inhibitor;
KW Reference proteome; Thiol protease inhibitor.
FT CHAIN <1..>35
FT /note="Leukocyte cysteine proteinase inhibitor 2"
FT /id="PRO_0000207150"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 3
FT /note="Reactive site"
FT /evidence="ECO:0000250"
FT NON_TER 1
FT NON_TER 35
SQ SEQUENCE 35 AA; 3925 MW; 6A3A4167907D9B94 CRC64;
LAGGLTEPRP ADTEIQEIAN KVKPQLEEKT NKKYD