ID   CPIA_ACIAD              Reviewed;         138 AA.
AC   Q6F9U4;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   23-FEB-2022, entry version 61.
DE   RecName: Full=PilB-specific inhibitory protein CpiA {ECO:0000303|PubMed:34145281};
DE   AltName: Full=Competence pilus inhibition actuator {ECO:0000303|PubMed:34145281};
GN   Name=cpiA {ECO:0000303|PubMed:34145281};
GN   OrderedLocusNames=ACIAD2394 {ECO:0000312|EMBL:CAG69169.1};
OS   Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=15514110; DOI=10.1093/nar/gkh910;
RA   Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA   Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA   Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT   "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT   a versatile and naturally transformation competent bacterium.";
RL   Nucleic Acids Res. 32:5766-5779(2004).
RN   [2]
RP   FUNCTION, INTERACTION WITH PILB, AND INDUCTION.
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=34145281; DOI=10.1038/s41467-021-24124-6;
RA   Ellison C.K., Dalia T.N., Klancher C.A., Shaevitz J.W., Gitai Z.,
RA   Dalia A.B.;
RT   "Acinetobacter baylyi regulates type IV pilus synthesis by employing two
RT   extension motors and a motor protein inhibitor.";
RL   Nat. Commun. 12:3744-3744(2021).
CC   -!- FUNCTION: Acts as a PilB inhibitor to control natural transformation.
CC       Inhibits type IV pili (T4P) extension by specifically binding and
CC       inhibiting the pilus extension ATPase PilB but not TfpB. This activity
CC       probably modulates T4P extension under different environmental
CC       conditions. {ECO:0000269|PubMed:34145281}.
CC   -!- SUBUNIT: Interacts with PilB but not with TfpB.
CC       {ECO:0000269|PubMed:34145281}.
CC   -!- INDUCTION: Repressed by CpiR (PubMed:34145281). Different environmental
CC       conditions may derepress cpiA to decrease pilus activity
CC       (PubMed:34145281). {ECO:0000269|PubMed:34145281}.
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DR   EMBL; CR543861; CAG69169.1; -; Genomic_DNA.
DR   EnsemblBacteria; CAG69169; CAG69169; ACIAD2394.
DR   KEGG; aci:ACIAD2394; -.
DR   HOGENOM; CLU_1850773_0_0_6; -.
DR   Proteomes; UP000000430; Chromosome.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..138
FT                   /note="PilB-specific inhibitory protein CpiA"
FT                   /id="PRO_0000453799"
SQ   SEQUENCE   138 AA;  16564 MW;  BE5F674B69F587D1 CRC64;
     MIMKLVSDQI QERKFIIEFQ LFNLIDELGL SVKKDHERKI FIYALLYVQL MHQPYSAMNT
     ISQLEPVTTY EKIKISYYTN YLSTYLSTSY SQERERIISI ISKTFIDSIN PEMNLYNFND
     FVTMFAFKKL LQQVFHEN