ID   CPIR_ACIAD              Reviewed;         110 AA.
AC   Q6F9U5;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Competence pilus inhibition repressor {ECO:0000303|PubMed:34145281};
GN   Name=cpiR {ECO:0000303|PubMed:34145281};
GN   OrderedLocusNames=ACIAD2393 {ECO:0000312|EMBL:CAG69168.1};
OS   Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Moraxellales; Moraxellaceae;
OC   Acinetobacter.
OX   NCBI_TaxID=62977;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=15514110; DOI=10.1093/nar/gkh910;
RA   Barbe V., Vallenet D., Fonknechten N., Kreimeyer A., Oztas S., Labarre L.,
RA   Cruveiller S., Robert C., Duprat S., Wincker P., Ornston L.N.,
RA   Weissenbach J., Marliere P., Cohen G.N., Medigue C.;
RT   "Unique features revealed by the genome sequence of Acinetobacter sp. ADP1,
RT   a versatile and naturally transformation competent bacterium.";
RL   Nucleic Acids Res. 32:5766-5779(2004).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 33305 / BD413 / ADP1;
RX   PubMed=34145281; DOI=10.1038/s41467-021-24124-6;
RA   Ellison C.K., Dalia T.N., Klancher C.A., Shaevitz J.W., Gitai Z.,
RA   Dalia A.B.;
RT   "Acinetobacter baylyi regulates type IV pilus synthesis by employing two
RT   extension motors and a motor protein inhibitor.";
RL   Nat. Commun. 12:3744-3744(2021).
CC   -!- FUNCTION: Represses transcription of the PilB-specific inhibitory
CC       protein CpiA. {ECO:0000269|PubMed:34145281}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the gene results in a 100-fold
CC       reduction in transformation. {ECO:0000269|PubMed:34145281}.
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DR   EMBL; CR543861; CAG69168.1; -; Genomic_DNA.
DR   RefSeq; WP_004928260.1; NC_005966.1.
DR   SMR; Q6F9U5; -.
DR   STRING; 62977.ACIAD2393; -.
DR   EnsemblBacteria; CAG69168; CAG69168; ACIAD2393.
DR   GeneID; 45234705; -.
DR   KEGG; aci:ACIAD2393; -.
DR   eggNOG; ENOG5034AH9; Bacteria.
DR   HOGENOM; CLU_2260750_0_0_6; -.
DR   OrthoDB; 1933795at2; -.
DR   BioCyc; ASP62977:ACIAD_RS10940-MON; -.
DR   Proteomes; UP000000430; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   SMART; SM00530; HTH_XRE; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
DR   PROSITE; PS50943; HTH_CROC1; 1.
PE   4: Predicted;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..110
FT                   /note="Competence pilus inhibition repressor"
FT                   /id="PRO_0000453800"
FT   DOMAIN          7..61
FT                   /note="HTH cro/C1-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
FT   DNA_BIND        18..37
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00257"
SQ   SEQUENCE   110 AA;  12695 MW;  E4C86B7E36AB4CB9 CRC64;
     MDIGRAVRFL RKRQGWTQQQ LADFSHTSKS NISNLENGNQ GYSPAILEYL AKAFNCSVSQ
     IFLLAENMDN EGNLLKDWQH MPIDVLFIQL PQEVQCQLKH LIFTLIDTKK