ID   CPKA_PYRHO              Reviewed;         314 AA.
AC   O59023;
DT   29-AUG-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Carbamate kinase;
DE            EC=2.7.2.2;
DE   AltName: Full=Carbamate kinase-like carbamoylphosphate synthase;
GN   Name=cpkA; OrderedLocusNames=PH1282;
OS   Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC
OS   100139 / OT-3).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Pyrococcus.
OX   NCBI_TaxID=70601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3;
RX   PubMed=9679194; DOI=10.1093/dnares/5.2.55;
RA   Kawarabayasi Y., Sawada M., Horikawa H., Haikawa Y., Hino Y., Yamamoto S.,
RA   Sekine M., Baba S., Kosugi H., Hosoyama A., Nagai Y., Sakai M., Ogura K.,
RA   Otsuka R., Nakazawa H., Takamiya M., Ohfuku Y., Funahashi T., Tanaka T.,
RA   Kudoh Y., Yamazaki J., Kushida N., Oguchi A., Aoki K., Yoshizawa T.,
RA   Nakamura Y., Robb F.T., Horikoshi K., Masuchi Y., Shizuya H., Kikuchi H.;
RT   "Complete sequence and gene organization of the genome of a hyper-
RT   thermophilic archaebacterium, Pyrococcus horikoshii OT3.";
RL   DNA Res. 5:55-76(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; BA000001; BAA30385.1; -; Genomic_DNA.
DR   PIR; G71073; G71073.
DR   RefSeq; WP_010885368.1; NC_000961.1.
DR   AlphaFoldDB; O59023; -.
DR   SMR; O59023; -.
DR   STRING; 70601.3257702; -.
DR   EnsemblBacteria; BAA30385; BAA30385; BAA30385.
DR   GeneID; 1443604; -.
DR   KEGG; pho:PH1282; -.
DR   eggNOG; arCOG00863; Archaea.
DR   OMA; QPMDVAG; -.
DR   OrthoDB; 77437at2157; -.
DR   Proteomes; UP000000752; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006525; P:arginine metabolic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN           1..314
FT                   /note="Carbamate kinase"
FT                   /id="PRO_0000185150"
SQ   SEQUENCE   314 AA;  34235 MW;  BCE87715B72E8CAE CRC64;
     MPERVVIALG GNALQQRGQK GTYDEMMENV RKTAKQIAEI IARGYEVVIT HGNGPQVGTI
     LLHMDAGQSL HGIPAQPMDV AGAMSQGWIG YMIQQALRNE LRKRGIEKEV VTIITQTIVD
     KKDPAFQNPT KPVGPFYDEK TAKKLAKEKG WVVKEDAGRG WRRVVPSPDP KGHVEAETIR
     RLVESGIIVI ASGGGGVPVI EENGEIKGVE AVIDKDLAGE KLAEEVNADI LMILTDVNGA
     ALYYGTEKET WLRNVKVEEL EKYYQEGHFK AGSMGPKVLA AIRFIKNGGK RAIIAHLEKA
     VEALEGKTGT QVTP