ID   CPKA_THEKO              Reviewed;         315 AA.
AC   Q5JHG5;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Carbamate kinase;
DE            EC=2.7.2.2;
DE   AltName: Full=Carbamate kinase-like carbamoylphosphate synthase;
GN   Name=cpkA; OrderedLocusNames=TK2158;
OS   Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)
OS   (Pyrococcus kodakaraensis (strain KOD1)).
OC   Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae;
OC   Thermococcus.
OX   NCBI_TaxID=69014;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-918 / JCM 12380 / KOD1;
RX   PubMed=15710748; DOI=10.1101/gr.3003105;
RA   Fukui T., Atomi H., Kanai T., Matsumi R., Fujiwara S., Imanaka T.;
RT   "Complete genome sequence of the hyperthermophilic archaeon Thermococcus
RT   kodakaraensis KOD1 and comparison with Pyrococcus genomes.";
RL   Genome Res. 15:352-363(2005).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + hydrogencarbonate + NH4(+) = ADP + carbamoyl phosphate +
CC         H(+) + H2O; Xref=Rhea:RHEA:10152, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:17544, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:58228, ChEBI:CHEBI:456216; EC=2.7.2.2;
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the carbamate kinase family. {ECO:0000305}.
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DR   EMBL; AP006878; BAD86347.1; -; Genomic_DNA.
DR   RefSeq; WP_011251108.1; NC_006624.1.
DR   AlphaFoldDB; Q5JHG5; -.
DR   SMR; Q5JHG5; -.
DR   STRING; 69014.TK2158; -.
DR   EnsemblBacteria; BAD86347; BAD86347; TK2158.
DR   GeneID; 3235378; -.
DR   KEGG; tko:TK2158; -.
DR   PATRIC; fig|69014.16.peg.2113; -.
DR   eggNOG; arCOG00863; Archaea.
DR   HOGENOM; CLU_076278_0_0_2; -.
DR   InParanoid; Q5JHG5; -.
DR   OMA; QPMDVAG; -.
DR   OrthoDB; 77437at2157; -.
DR   PhylomeDB; Q5JHG5; -.
DR   Proteomes; UP000000536; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0008804; F:carbamate kinase activity; IBA:GO_Central.
DR   GO; GO:0019546; P:arginine deiminase pathway; IBA:GO_Central.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd04235; AAK_CK; 1.
DR   Gene3D; 3.40.1160.10; -; 1.
DR   InterPro; IPR036393; AceGlu_kinase-like_sf.
DR   InterPro; IPR001048; Asp/Glu/Uridylate_kinase.
DR   InterPro; IPR003964; Carb_kinase.
DR   PANTHER; PTHR30409; PTHR30409; 1.
DR   Pfam; PF00696; AA_kinase; 1.
DR   PIRSF; PIRSF000723; Carbamate_kin; 1.
DR   SUPFAM; SSF53633; SSF53633; 1.
DR   TIGRFAMs; TIGR00746; arcC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Kinase; Nucleotide-binding; Reference proteome;
KW   Transferase.
FT   CHAIN           1..315
FT                   /note="Carbamate kinase"
FT                   /id="PRO_0000185151"
SQ   SEQUENCE   315 AA;  34105 MW;  6A1F68A70288319B CRC64;
     MKRVVIALGG NAILQRGQKG TYEEQMENVR RTAKQIADII LDGDYEVVIT HGNGPQVGAL
     LLHMDAGQQV YGIPAQPMDV AGAMTQGQIG YMIGQALINE LRKRGVEKPV ATIVTQTIVD
     KNDPAFQNPS KPVGPFYDEE TAKKLAKEKG WTVIEDAGRG WRRVVPSPDP KGHVEAPVIV
     DLVEKGFIVI ASGGGGVPVI EENGELKGVE AVIDKDLAGE KLAEEVKADI FMILTDVNGA
     AINYGKPDEK WLGKVTVDEL KRYYKEGHFK KGSMGPKVLA AIRFVEWGGE RAVIASLDRA
     VEALEGKTGT QVVRE