ID   CPLN2_DANRE             Reviewed;         252 AA.
AC   Q66JN8;
DT   17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Ciliogenesis and planar polarity effector 2 {ECO:0000305};
DE   AltName: Full=REM2- and Rab-like small GTPase 1 {ECO:0000250|UniProtKB:A2A825};
GN   Name=cplane2; Synonyms=rsg1; ORFNames=zgc:101035;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential effector of the planar cell polarity signaling
CC       pathway. Plays a role in targeted membrane trafficking most probably at
CC       the level of vesicle fusion with membranes. Involved in cilium
CC       biogenesis by regulating the transport of cargo proteins to the basal
CC       body and to the apical tips of cilia. More generally involved in
CC       exocytosis in secretory cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q6GNL4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q6GNL4}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC080841; AAH80841.1; -; mRNA.
DR   RefSeq; NP_001004649.1; NM_001004649.1.
DR   AlphaFoldDB; Q66JN8; -.
DR   SMR; Q66JN8; -.
DR   STRING; 7955.ENSDARP00000028805; -.
DR   PaxDb; Q66JN8; -.
DR   PRIDE; Q66JN8; -.
DR   DNASU; 447911; -.
DR   GeneID; 447911; -.
DR   KEGG; dre:447911; -.
DR   CTD; 79363; -.
DR   ZFIN; ZDB-GENE-040912-80; cplane2.
DR   eggNOG; KOG0395; Eukaryota.
DR   InParanoid; Q66JN8; -.
DR   OrthoDB; 1324082at2759; -.
DR   PhylomeDB; Q66JN8; -.
DR   PRO; PR:Q66JN8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0017157; P:regulation of exocytosis; ISS:UniProtKB.
DR   GO; GO:0031338; P:regulation of vesicle fusion; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039677; RSG1.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR14983; PTHR14983; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Exocytosis; GTP-binding; Nucleotide-binding;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..252
FT                   /note="Ciliogenesis and planar polarity effector 2"
FT                   /id="PRO_0000284540"
FT   REGION          46..252
FT                   /note="Small GTPase-like"
FT   BINDING         62..67
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         173..176
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   252 AA;  28355 MW;  BA56A614B4CAA5C8 CRC64;
     MSVPPGSIIV SDWHRCPDSR EFFSKILHKK RRRKFGLLEA PMMPPQMNVD LVRYKVFLSG
     KTGVGKSALA ARLAGLDLPK MHYETTGIET TVVFWPVRLK ESGRVLFFRF ELWDCGESAM
     RRFDHMLLSC KEKVDAILFL FSFTDRGSFD DLTNQISRIT EPSDRVVKLV VGTKFDLFMH
     TDVTESDVTH FQEVWGLPVF RVGGDVSAGL GEVAPLLNAL AENLWHQDCM AASSVSISPQ
     AALRETSSEI IV