CPLN2_MOUSE
ID CPLN2_MOUSE Reviewed; 258 AA.
AC A2A825;
DT 17-APR-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=Ciliogenesis and planar polarity effector 2 {ECO:0000305};
DE AltName: Full=REM2- and Rab-like small GTPase 1 {ECO:0000250|UniProtKB:Q9BU20};
GN Name=Cplane2; Synonyms=Gm723, Rsg1 {ECO:0000250|UniProtKB:Q9BU20};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Potential effector of the planar cell polarity signaling
CC pathway. Plays a role in targeted membrane trafficking most probably at
CC the level of vesicle fusion with membranes. Involved in cilium
CC biogenesis by regulating the transport of cargo proteins to the basal
CC body and to the apical tips of cilia. More generally involved in
CC exocytosis in secretory cells (By similarity).
CC {ECO:0000250|UniProtKB:Q6GNL4}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC {ECO:0000250|UniProtKB:Q6GNL4}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC {ECO:0000305}.
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DR EMBL; AL607087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS38937.1; -.
DR RefSeq; NP_001074643.1; NM_001081174.2.
DR PDB; 7Q3E; EM; 3.35 A; D=1-258.
DR PDBsum; 7Q3E; -.
DR AlphaFoldDB; A2A825; -.
DR SMR; A2A825; -.
DR STRING; 10090.ENSMUSP00000095422; -.
DR iPTMnet; A2A825; -.
DR PhosphoSitePlus; A2A825; -.
DR PaxDb; A2A825; -.
DR PRIDE; A2A825; -.
DR ProteomicsDB; 257043; -.
DR Antibodypedia; 29156; 49 antibodies from 15 providers.
DR Ensembl; ENSMUST00000097813; ENSMUSP00000095422; ENSMUSG00000073733.
DR GeneID; 76166; -.
DR KEGG; mmu:76166; -.
DR UCSC; uc012doa.1; mouse.
DR CTD; 79363; -.
DR MGI; MGI:1923416; Cplane2.
DR VEuPathDB; HostDB:ENSMUSG00000073733; -.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00390000006521; -.
DR HOGENOM; CLU_094613_0_0_1; -.
DR InParanoid; A2A825; -.
DR OMA; LWHQDCV; -.
DR OrthoDB; 1324082at2759; -.
DR PhylomeDB; A2A825; -.
DR TreeFam; TF329319; -.
DR BioGRID-ORCS; 76166; 5 hits in 71 CRISPR screens.
DR PRO; PR:A2A825; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; A2A825; protein.
DR Bgee; ENSMUSG00000073733; Expressed in embryonic facial prominence and 60 other tissues.
DR ExpressionAtlas; A2A825; baseline and differential.
DR GO; GO:0005814; C:centriole; IDA:MGI.
DR GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR GO; GO:0097546; C:ciliary base; IDA:MGI.
DR GO; GO:0035869; C:ciliary transition zone; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IMP:MGI.
DR GO; GO:0035082; P:axoneme assembly; IMP:MGI.
DR GO; GO:0060271; P:cilium assembly; IDA:MGI.
DR GO; GO:1904888; P:cranial skeletal system development; IMP:MGI.
DR GO; GO:0003274; P:endocardial cushion fusion; IMP:MGI.
DR GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR GO; GO:0060173; P:limb development; IMP:MGI.
DR GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR GO; GO:0016485; P:protein processing; IMP:MGI.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0017157; P:regulation of exocytosis; ISS:UniProtKB.
DR GO; GO:1901620; P:regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; IMP:MGI.
DR GO; GO:0031338; P:regulation of vesicle fusion; ISS:UniProtKB.
DR GO; GO:0007224; P:smoothened signaling pathway; IMP:MGI.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039677; RSG1.
DR InterPro; IPR001806; Small_GTPase.
DR PANTHER; PTHR14983; PTHR14983; 1.
DR Pfam; PF00071; Ras; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell projection; Cilium; Cilium biogenesis/degradation;
KW Cytoplasm; Cytoskeleton; Exocytosis; GTP-binding; Nucleotide-binding;
KW Protein transport; Reference proteome; Transport.
FT CHAIN 1..258
FT /note="Ciliogenesis and planar polarity effector 2"
FT /id="PRO_0000284539"
FT REGION 51..258
FT /note="Small GTPase-like"
FT BINDING 62..69
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
FT BINDING 175..178
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000250"
SQ SEQUENCE 258 AA; 28422 MW; 2AE5CB87F791780A CRC64;
MARPPMHGSV IVPDWHETVE GKEYLACILR KNRRREFGLL ERPVLPPSVV IDTASYKIFV
SGKSGVGKTA LVAKLAGLEV PIVHHETTGI QTTVVFWPAK LKASDCVVMF RFEFWDCGES
ALKKFDHMLP ACKENADAFL FLFSFTDRAS FEDLPGQLTR VAGEAPGLVK IVIGSKFDQY
MHTDVPARDL TAFRQAWELP LFRVKSVPGR RLADGRTLDG RAGLADTAHV LNGLAEQLWH
QDQVAAGLLP SSPESAPG
