ID   CPLN2_XENTR             Reviewed;         255 AA.
AC   B7ZTR0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Ciliogenesis and planar polarity effector 2 {ECO:0000305};
DE   AltName: Full=REM2- and Rab-like small GTPase 1 {ECO:0000250|UniProtKB:Q6GNL4};
GN   Name=cplane2; Synonyms=rsg1 {ECO:0000250|UniProtKB:Q6GNL4};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potential effector of the planar cell polarity signaling
CC       pathway. Plays a role in targeted membrane trafficking most probably at
CC       the level of vesicle fusion with membranes. Involved in cilium
CC       biogenesis by regulating the transport of cargo proteins to the basal
CC       body and to the apical tips of cilia. More generally involved in
CC       exocytosis in secretory cells (By similarity).
CC       {ECO:0000250|UniProtKB:Q6GNL4}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body
CC       {ECO:0000250|UniProtKB:Q6GNL4}.
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
CC       {ECO:0000305}.
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DR   EMBL; BC170963; AAI70963.1; -; mRNA.
DR   AlphaFoldDB; B7ZTR0; -.
DR   SMR; B7ZTR0; -.
DR   STRING; 8364.ENSXETP00000029459; -.
DR   PaxDb; B7ZTR0; -.
DR   eggNOG; KOG0395; Eukaryota.
DR   InParanoid; B7ZTR0; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0017157; P:regulation of exocytosis; ISS:UniProtKB.
DR   GO; GO:0031338; P:regulation of vesicle fusion; ISS:UniProtKB.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR039677; RSG1.
DR   InterPro; IPR001806; Small_GTPase.
DR   PANTHER; PTHR14983; PTHR14983; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Cilium biogenesis/degradation; Cytoplasm;
KW   Cytoskeleton; Exocytosis; GTP-binding; Nucleotide-binding;
KW   Protein transport; Reference proteome; Transport.
FT   CHAIN           1..255
FT                   /note="Ciliogenesis and planar polarity effector 2"
FT                   /id="PRO_0000409247"
FT   REGION          52..255
FT                   /note="Small GTPase-like"
FT   BINDING         64..71
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
FT   BINDING         177..180
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   255 AA;  28362 MW;  3695504FB3842C89 CRC64;
     MALAEAPRPG PLMDPEWHGS PEGKEYLGCI LRKKKRKFFG LIERPVLSPQ LPADIASYKL
     FVCGRSGAGK TSFIAKLAGL EVPSMHHETT GIQTTCVYWP VRPTHSARPV IFRFQFWDCG
     EGALRKFDHI LPACKEMADA VLFLFSFTDR SSFEDVPALI SRTLGQEEDV ARVVIGTKLD
     QYTHTDVTEN DLRDFQRTWQ LPVMRVRSVN GPRVAEGRGL DGRVGLVECA PVLNGLAEIL
     WRRDQVIAGL VGGAD