ID   CPLX1_CAEBR             Reviewed;         143 AA.
AC   Q60PP8; A8Y1N9;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Putative complexin-1;
GN   Name=cpx-1; ORFNames=CBG22157;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Positively regulates a late step in synaptic vesicle
CC       exocytosis. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the complexin/synaphin family. {ECO:0000305}.
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DR   EMBL; HE601428; CAP38809.1; -; Genomic_DNA.
DR   RefSeq; XP_002638930.1; XM_002638884.1.
DR   AlphaFoldDB; Q60PP8; -.
DR   SMR; Q60PP8; -.
DR   STRING; 6238.CBG22157; -.
DR   EnsemblMetazoa; CBG22157.1; CBG22157.1; WBGene00040779.
DR   GeneID; 8580926; -.
DR   KEGG; cbr:CBG_22157; -.
DR   CTD; 8580926; -.
DR   WormBase; CBG22157; CBP05286; WBGene00040779; Cbr-cpx-1.
DR   eggNOG; ENOG502S3I2; Eukaryota.
DR   HOGENOM; CLU_132159_0_0_1; -.
DR   InParanoid; Q60PP8; -.
DR   OMA; MASFVMK; -.
DR   OrthoDB; 1513799at2759; -.
DR   Proteomes; UP000008549; Chromosome I.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR   GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR   GO; GO:0019905; F:syntaxin binding; IEA:InterPro.
DR   GO; GO:0046928; P:regulation of neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0016079; P:synaptic vesicle exocytosis; IBA:GO_Central.
DR   InterPro; IPR008849; Synaphin.
DR   PANTHER; PTHR16705; PTHR16705; 1.
DR   Pfam; PF05835; Synaphin; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Exocytosis; Neurotransmitter transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..143
FT                   /note="Putative complexin-1"
FT                   /id="PRO_0000240245"
FT   REGION          15..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          40..71
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        23..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   143 AA;  15952 MW;  47D0A9A701C69900 CRC64;
     MAGFLMKQMV GNQLNEVTGG LGLKDDGGEK TETGEDPEVV AARLEQEERR KEKHRKMEQE
     REKMRQGIRD KYAIKKKEEG VAMDFTEGRI GGPRKTPEEI AAEMNAEDDS IIGQLGLTEQ
     VEKAKTMATG AFETVKGFFP FGK