CPLX1_CAEEL
ID CPLX1_CAEEL Reviewed; 143 AA.
AC Q9GUM7;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Putative complexin-1;
GN Name=cpx-1; ORFNames=Y73E7A.4;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: Positively regulates a late step in synaptic vesicle
CC exocytosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complexin/synaphin family. {ECO:0000305}.
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DR EMBL; FO081821; CCD73528.1; -; Genomic_DNA.
DR RefSeq; NP_490868.1; NM_058467.3.
DR AlphaFoldDB; Q9GUM7; -.
DR SMR; Q9GUM7; -.
DR STRING; 6239.Y73E7A.4; -.
DR TCDB; 1.F.1.1.3; the synaptosomal vesicle fusion pore (svf-pore) family.
DR EPD; Q9GUM7; -.
DR PaxDb; Q9GUM7; -.
DR PeptideAtlas; Q9GUM7; -.
DR EnsemblMetazoa; Y73E7A.4.1; Y73E7A.4.1; WBGene00022271.
DR GeneID; 190666; -.
DR KEGG; cel:CELE_Y73E7A.4; -.
DR UCSC; Y73E7A.4; c. elegans.
DR CTD; 190666; -.
DR WormBase; Y73E7A.4; CE26415; WBGene00022271; cpx-1.
DR eggNOG; ENOG502S3I2; Eukaryota.
DR GeneTree; ENSGT00950000182938; -.
DR HOGENOM; CLU_132159_0_0_1; -.
DR InParanoid; Q9GUM7; -.
DR OMA; MASFVMK; -.
DR OrthoDB; 1513799at2759; -.
DR PhylomeDB; Q9GUM7; -.
DR Reactome; R-CEL-181429; Serotonin Neurotransmitter Release Cycle.
DR Reactome; R-CEL-181430; Norepinephrine Neurotransmitter Release Cycle.
DR Reactome; R-CEL-210500; Glutamate Neurotransmitter Release Cycle.
DR Reactome; R-CEL-212676; Dopamine Neurotransmitter Release Cycle.
DR Reactome; R-CEL-264642; Acetylcholine Neurotransmitter Release Cycle.
DR Reactome; R-CEL-888590; GABA synthesis, release, reuptake and degradation.
DR PRO; PR:Q9GUM7; -.
DR Proteomes; UP000001940; Chromosome I.
DR Bgee; WBGene00022271; Expressed in larva and 3 other tissues.
DR GO; GO:0030424; C:axon; IDA:WormBase.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IDA:WormBase.
DR GO; GO:0043195; C:terminal bouton; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0019905; F:syntaxin binding; IEA:InterPro.
DR GO; GO:0046928; P:regulation of neurotransmitter secretion; IBA:GO_Central.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IBA:GO_Central.
DR InterPro; IPR008849; Synaphin.
DR PANTHER; PTHR16705; PTHR16705; 1.
DR Pfam; PF05835; Synaphin; 1.
PE 3: Inferred from homology;
KW Coiled coil; Cytoplasm; Exocytosis; Neurotransmitter transport;
KW Reference proteome; Transport.
FT CHAIN 1..143
FT /note="Putative complexin-1"
FT /id="PRO_0000240246"
FT REGION 16..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 40..71
FT /evidence="ECO:0000255"
FT COMPBIAS 23..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 143 AA; 15943 MW; E52A0E859D8DA625 CRC64;
MAGFLMKQMV GNQLSEVTGG LGMKDDGGEK TETGEDPEVI AARLEQEERR KEKHRKMENE
REKMRQGIRD KYAIKKKEEG VAMDFTEGRI GGPRKTPEEI AAEMNAEDDS LIGQLGLTEQ
VEKAKTMATG AFETVKGFFP FGK
