ID   CPLX1_NARJA             Reviewed;         133 AA.
AC   O42106;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Complexin-1;
DE   AltName: Full=NJ-synaphin-2;
OS   Narke japonica (Japanese electric ray) (Torpedo japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Torpediniformes; Narkidae; Narke.
OX   NCBI_TaxID=62965;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBUNIT.
RC   TISSUE=Electric lobe;
RX   PubMed=9302098; DOI=10.1016/s0304-3940(97)00586-7;
RA   Ishizuka T., Saisu H., Suzuki T., Kirino Y., Abe T.;
RT   "Molecular cloning of synaphins/complexins, cytosolic proteins involved in
RT   transmitter release, in the electric organ of an electric ray (Narke
RT   japonica).";
RL   Neurosci. Lett. 232:107-110(1997).
CC   -!- FUNCTION: Positively regulates a late step in synaptic vesicle
CC       exocytosis. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to the SNARE core complex containing SNAP25, VAMP2 and
CC       syntaxin-1. {ECO:0000269|PubMed:9302098}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Nervous system. Present in electric organ (at
CC       protein level). {ECO:0000269|PubMed:9302098}.
CC   -!- SIMILARITY: Belongs to the complexin/synaphin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB004245; BAA22605.1; -; mRNA.
DR   AlphaFoldDB; O42106; -.
DR   SMR; O42106; -.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0019905; F:syntaxin binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008849; Synaphin.
DR   PANTHER; PTHR16705; PTHR16705; 1.
DR   Pfam; PF05835; Synaphin; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Exocytosis; Neurotransmitter transport; Transport.
FT   CHAIN           1..133
FT                   /note="Complexin-1"
FT                   /id="PRO_0000144873"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          85..112
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          28..60
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        18..40
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   133 AA;  14930 MW;  9511EF64F27923D5 CRC64;
     MDFVMKQALG GATKDMGKML GGDEEKDPDA EKKEEERLEA LRQAEEERAG KYAKMEAERE
     VMRQGIRDKY GIKKKEEKEA EAMAAMEAQA EGSLTRPKKA IPAGCGDEDE EEESILDTVL
     KYLPGPLQDM FKK