ID   CPLX2_NARJA             Reviewed;         134 AA.
AC   O42105;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Complexin-2;
DE   AltName: Full=NJ-synaphin-1A;
OS   Narke japonica (Japanese electric ray) (Torpedo japonica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes;
OC   Elasmobranchii; Batoidea; Torpediniformes; Narkidae; Narke.
OX   NCBI_TaxID=62965;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND SUBUNIT.
RC   TISSUE=Electric lobe;
RX   PubMed=9302098; DOI=10.1016/s0304-3940(97)00586-7;
RA   Ishizuka T., Saisu H., Suzuki T., Kirino Y., Abe T.;
RT   "Molecular cloning of synaphins/complexins, cytosolic proteins involved in
RT   transmitter release, in the electric organ of an electric ray (Narke
RT   japonica).";
RL   Neurosci. Lett. 232:107-110(1997).
CC   -!- FUNCTION: Positively regulates a late step in synaptic vesicle
CC       exocytosis. {ECO:0000250}.
CC   -!- SUBUNIT: Binds to the SNARE core complex containing SNAP25, VAMP2 and
CC       STX1A. {ECO:0000269|PubMed:9302098}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000250|UniProtKB:P84087}. Presynapse
CC       {ECO:0000250|UniProtKB:P84087}. Nucleus {ECO:0000250|UniProtKB:P84087}.
CC       Perikaryon {ECO:0000250|UniProtKB:P84087}.
CC   -!- TISSUE SPECIFICITY: Nervous system. Present in electric organ (at
CC       protein level). {ECO:0000269|PubMed:9302098}.
CC   -!- SIMILARITY: Belongs to the complexin/synaphin family. {ECO:0000305}.
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DR   EMBL; AB004243; BAA22603.1; -; mRNA.
DR   AlphaFoldDB; O42105; -.
DR   SMR; O42105; -.
DR   GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-KW.
DR   GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0098793; C:presynapse; IEA:UniProtKB-SubCell.
DR   GO; GO:0019905; F:syntaxin binding; IEA:InterPro.
DR   GO; GO:0006887; P:exocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW.
DR   InterPro; IPR008849; Synaphin.
DR   PANTHER; PTHR16705; PTHR16705; 1.
DR   Pfam; PF05835; Synaphin; 1.
PE   1: Evidence at protein level;
KW   Cell projection; Coiled coil; Cytoplasm; Exocytosis;
KW   Neurotransmitter transport; Nucleus; Synapse; Transport.
FT   CHAIN           1..134
FT                   /note="Complexin-2"
FT                   /id="PRO_0000144878"
FT   REGION          1..114
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          29..84
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        18..86
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   134 AA;  15438 MW;  CC98897243E80C65 CRC64;
     MDFVMKQALG GATKDMGKML GGDEEKDPDA QKKEEERQEA LRQQEDERKQ KHIRMETERE
     KVRQQIRDKY GLKKKEEKEA EEKAAMEAPI EGSLTRPKKA IPAGCGDEDE EDEESILDTV
     LKYLPGPLQD MFKK